Month: May 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 455-01-6, name is 2-(3-(Trifluoromethyl)phenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 455-01-6

Example 86 3-(Trifluoromethyl)phenethyl N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline (85 mg) was added to toluene/triethylamine = 10/1 (9 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (125 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethylphenethyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (69 mg, yield 46%). 1H-NMR (CDCl3, 400 MHz): 8.79 (1H, s), 8.27 – 8.34 (1H, m), 8.03 (1H, s), 7.30 – 7.62 (6H, m), 7.24 – 7.23 (2H, m), 4.46 (2H, t, J = 6.8 Hz), 4.18 (3H, s), 4.11 (3H, s), 3.10 (2H, t, J = 6.9 Hz) Mass spectrometry value (ESI-MS, m/z): 549 (M++1)

With the rapid development of chemical substances, we look forward to future research findings about 455-01-6.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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Related Products of 14002-80-3 , The common heterocyclic compound, 14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To methyl hydroxypivalate (1.31 g, 9.89 mmol) were added tetrahydrofuran (40 ml), hydroxyphthalimide (3.23 g, 19.78 mmol) and triphenylphosphine (6.48 g, 24.73 mmol). After this solution was cooled to 0C, diisopropyl azodicarboxylate (4.87 ml, 24.73 mmol) was added dropwise to the solution. While being allowed to warm gradually, the reaction mixture was stirred for 12 hours, and concentrated under reduced pressure. The residue was roughly purified by silica gel column chromatography to give the title compound (922 mg). 1H-NMR(CDCl3, 400MHz) delta(PPM) 1.35(6H, s), 3.74(3H, s), 4.26(2H, s), 7.27-7.76(2H, m), 7.81-7.85(2H, m)

The synthetic route of 14002-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1780197; (2007); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17849-38-6, name is 2-Chlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H7ClO

In the installation of a stirrer, thermometer,In the reaction vessel of the distillation apparatus,3.1 mol of o-chlorobenzyl alcohol (2), 3.9 mol of aniline (3)Mass fraction 65% nitromethane 310ml, cuprous chloride 1.56mol, mixing evenly,The stirring speed was controlled at 160 rpm, the solution temperature was raised to 115 & lt; 0 & gt;Reaction 5h, Raising the solution temperature to 135 & lt; 0 & gt; C,Reaction 3h,The temperature of the solution was raised to 195 C,Reaction 120min,The solution temperature was lowered to 20 & lt; 0 &Adding ammonium nitrate solution 700ml,Mass fraction of 45% sodium bisulfite solution 130ml, 1.7kPa vacuum distillation,Fractions of 130-135 C were collected,Mass fraction of 75% triethylamine washing,In the mass fraction of 95% toluene recrystallization,To obtain the crystal o-chlorobenzonitrile 350.80g, yield 82%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17849-38-6, 2-Chlorobenzyl alcohol.

Reference:
Patent; Chengdu Chiba Longhua Petroleum Engineering Consulting Co., Ltd; Guan, Genan; (4 pag.)CN105566156; (2016); A;,
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Synthetic Route of 69605-90-9, Adding some certain compound to certain chemical reactions, such as: 69605-90-9, name is [1,1′-Biphenyl]-3-ylmethanol,molecular formula is C13H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69605-90-9.

Under nitrogen atmosphere, to a stirred mixture of 3-phenylphenyl methanol (0.3 g, 1.63 mmol) in dry CH2C12 (3 mL), Et3N (0.340 mL, 2.44 mmol) and di-2-pyridyl carbonate (0.387 g, 1.79 mmol) were added. The reaction mixture was left at rt for 15h, diluted with CH2C12 and washed first with a saturated NH4C1 solution (3 mL) and subsequently with a saturated NaHC03 solution (3×3 mL). The organic fraction was dried over Na2S04, filtered and concentrated to dryness to afford a dark oil (0.487 g, 98%), as a mixture (ratio 1:3) of 3- phenylphenyl)methyl-2-pyridyl-carbonate and 3-phenylphenyl)methyl-2-oxopyridine 1- carboxylate. The mixture of isomers was not separated and used in the next step without any further purification. MS (ESI) m/z: 328 [M-Na]+, 306 [M-H]+, 262, 167.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 69605-90-9, [1,1′-Biphenyl]-3-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; IIT – ISTITUTO ITALIANO DI TECNOLOGIA; UNIVERSITY DEGLI STUDI DI URBINO; UNIVERSITA DEGLI STUDI DI PARMA; PIOMELLI, Daniele; BANDIERA, Tiziano; MOR, Marco; TARZIA, Giorgio; BERTOZZI, Fabio; PONZANO, Stefano; WO2013/78430; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3279-95-6, 2-(Aminooxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Aminooxy)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-(Aminooxy)ethanol

To a solution of 1-(3-(3-(morpholinomethyl)quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethanone hydrochloride (79.3) (23 mg, 0.047 mmol) and 2-(aminooxy)ethanol (10.80 mg, 0.140 mmol) in MeOH (5 ml) was added 2 drops of HCl (2 N) by a 1-ml syringe to reach pH about 3 and the mixture was stirred in a sealed tube at 85 C. for 3 h. The mixture was evaporated to dryness and the residue was dissolved in water. The solution was neutralized by adding solid NaHCO3 until pH reached 9, then extracted by DCM (3×). The combined organic layers were washed by water again, dried over Na2SO4, filtered and evaporated. The residue was purified by preparative base HPLC (gradient eluent NB from 20/80 to 95/5. mobile phase A: NH4OH/CH3CN 0.04%; mobile phase B: NH4OH/H2O 0.04%). The desired fractions were collected, evaporated by BUCHI under 30 mbar at 35 C. to remove CH3CN. The remained solution was lyophilized to afford the title compound (12.2 mg, yield 54.2%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3279-95-6, 2-(Aminooxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue; US2013/245002; (2013); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13330-96-6, name is 4-(Dimethylamino)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-(Dimethylamino)butan-1-ol

Example S. Synthesis of MC4 Ether.[0294] MC4 Ether (Compound 15) having the structure shown below was synthesized as described below.Chemical Fotmuta: Omicron^Eta,, OmicronExact Mass: 627.6Molecular Wteirjit 628.1Bemena And sis: C.8222; K 13.00; N, 2.23; 0.2.55MC4 Ether[0295] A 50 mL RBF with stir-bar were flushed with nitrogen, and NaH (220 mg, 9 mmol), dimethylaminobutanol (1.05g, 9 mmol) and anh. benzene (10 mL) added. Aftereffervescence subsided, Compound 14 (440 mg, 0.75 mmol) was added and RM refluxed overnight at 90C. TLC indicated some product formation. The reaction was diluted to 40 mL with benzene, and quenched with ethanol (25 mL). It was then washed with water (40 mL), dried and concentrated. The crude product was purified to yield product as a pale yellow oil, 145 mg, 31%.

With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS, INC.; HEYES, James; WOOD, Mark; MARTIN, Alan; WO2011/141705; (2011); A1;,
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Related Products of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

(A) 3-Cyclopentyl-2-(3,4-dichloro-phenyl)-N-pyridin-2-yl-propionamide: A solution of triphenylphosphine (28.80 g, 109.8 mmol) and imidazole (14.9 g, 219.6 mmol) in methylene chloride (160 mL) was cooled to 0 C. and then slowly treated with iodine (27.87 g, 109.8 mmol). The reaction mixture was then treated dropwise with a solution of cyclopentylmethanol (10.0 g, 99.8 mmol) in methylene chloride (10 mL). The resulting reaction mixture was allowed to warm to 25 C., where it was stirred for 4 h. The reaction mixture was then diluted with water (50 mL), and the reaction mixture was further extracted with methylene chloride (3*20 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo at 25 C. The resulting solid was washed with pentane (4*50 mL) and filtered through a silica gel plug. The filtrate was concentrated in vacuo at 25 C. to afford iodomethylcyclopentane (18.48 g, 88%) as a clear colorless liquid: EI-HRMS m/e calcd for C6H11I1 (M+) 209.9906, found 209.9911.

Statistics shows that 3637-61-4 is playing an increasingly important role. we look forward to future research findings about Cyclopentanemethanol.

Reference:
Patent; Bizzarro, Fred Thomas; Corbett, Wendy Lea; Grippo, Joseph Francis; Haynes, Nancy-Ellen; Holland, George William; Kester, Robert Francis; Sarabu, Ramakanth; US2001/39344; (2001); A1;,
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Application of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To the stirred solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.0 g, 7.72 mmol) in water (5 mL) was added HC1 (3.86 mL, 23.15 mmol) at 0 C. To this, sodium nitrite (0.639 g, 9.26 mmol) in water was added drop wise at 0 C and stirred for 1 hour. Potassium iodide (1.922 g, 11.58 mmol) was added and the reaction mixture was stirred at ambient temperature. After completion of the reaction, the aqueous layer was extracted with DCM. The DCM layer was dried over sodium sulphate and evaporated. The crude material obtained was purified by flash column chromatography (silica gel, hexane and ethyl acetate). 1H NMR (DMSO-d6, 300 MHz): oe ppm 8.87(s, 1H), 7.92 (d, J=8.7Hz, 2H), 7.46 (d, J=8.lHz,2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; SAHU, Bichismita; MALI, Sunil, Vasantrao; SINGH, Deepak; KUMAR, Pramod, Bhaskar; DAWANGE, Mahesh; MISTRY, Hitesh; (108 pag.)WO2015/145371; (2015); A1;,
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Electric Literature of 647-42-7, Adding some certain compound to certain chemical reactions, such as: 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol,molecular formula is C8H5F13O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 647-42-7.

To a mixture of 2-(perfluorohexyl)ethanol (33.3 g, 46 mmol) and succinic anhydride (9.7 g, 49 mmol) and 10ml tetrahydrofuranand stirred at 100C And allowed to react for 60 minutes.Thereafter, the mixture was cooled to 30 DEG C, 100 mL of water was added, and the mixture was further cooled to 15 DEG C, and the precipitated crystals were collected by filtration to obtain carboxylic acid (1-2a). (39.7 g, 94%).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fuji Photo Film Co., Ltd.; Kato, Syunya; Yoshikawa, Masaru; (58 pag.)KR101634475; (2016); B1;,
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Electric Literature of 505-10-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.505-10-2, name is 3-(Methylthio)propan-1-ol, molecular formula is C4H10OS, molecular weight is 106.19, as common compound, the synthetic route is as follows.

The alcohol 23-a (200 g, 1900 mmol) was dissolved in CH2Cl2 (2000 ml). The mixture was cooled to 0 C. The m-CPBA 85% in water (970 g, 5700 mmol) was added portion wise keeping the temperature between 0 to 5 C. After addition, the mixture was allowed to warm to 25 C. and stirred for 15 h. The mixture was filtered through a celite pad. The filtrate was purified by flash column (Eluent: petroleum ether:ethyl acetate=3:1 and then ethyl acetate: methanol=10:1) to yield the intermediate 23-b (75 g, 29%).

Statistics shows that 505-10-2 is playing an increasingly important role. we look forward to future research findings about 3-(Methylthio)propan-1-ol.

Reference:
Patent; Jansen R&D Ireland; Tahri, Abdellah; Jonckers, Tim Hugo Maria; Raboisson, Pierre Jean-Marie Bernard; Vendeville, Sandrine Marie Helene; Hu, Lili; Demin, Samuel Dominique; Cooymans, Ludwig Paul; US2015/111868; (2015); A1;,
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