Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 13330-96-6, 4-(Dimethylamino)butan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13330-96-6, blongs to alcohols-buliding-blocks compound. Product Details of 13330-96-6

Example 8 Synthesis of MC4 Ether MC4 Ether (Compound 15) having the structure shown below was synthesized as described below. A 50 mL RBF with stir-bar were flushed with nitrogen, and NaH (220 mg, 9 mmol), dimethylaminobutanol (1.05 g, 9 mmol) and anh. benzene (10 mL) added. After effervescence subsided, Compound 14 (440 mg, 0.75 mmol) was added and RM refluxed overnight at 90 C. TLC indicated some product formation. The reaction was diluted to 40 mL with benzene, and quenched with ethanol (25 mL). It was then washed with water (40 mL), dried and concentrated. The crude product was purified to yield product as a pale yellow oil, 145 mg, 31%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13330-96-6, its application will become more common.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS INC; Heyes, James; Wood, Mark; Martin, Alan; Lee, Amy C.H.; Judge, Adam; Robbins, Marjorie; MacLachlan, Ian; US2013/123339; (2013); A1;,
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Electric Literature of 1113-21-9, Adding some certain compound to certain chemical reactions, such as: 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol,molecular formula is C20H34O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1113-21-9.

Menadiol monoacetate (4) (30.5 g) was dissolved in toluene (150 mL) and methanesulfonic acid (2 mL) was added. While this solution was being stirred, all-trans-geranyllinalool (5) (27.7 g) was added dropwise over 45 minutes at 49 to 51 C., the reaction was then continued for 2 hours and 55 minutes at the same temperature. The reaction solution was washed with aqueous sodium chloride solution (40 mL, 5%) twice. The organic layer was washed three times with a solution prepared by the addition of sodium hydrosulfite (2 g) to aqueous potassium hydroxide solution (40 mL, 10%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1113-21-9, 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai Co., Ltd.; US2007/60761; (2007); A1;,
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Related Products of 6850-39-1 ,Some common heterocyclic compound, 6850-39-1, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of I [3 4.ch1oro.8methoxy- I H,2H,3 Wcyc1openta[ciquinolin7yl }oxy)propyl}pyrroiidine (Intermediate Wi) (250 mg, 0.69 mmoi, 100 eq.), i,4-dioxane (5 ml.), and t-l3uONa (331 mg, 3.45 mmol, 500 eq.) in a microwave reaction vial was purged with N2 for 5 mm. To the solution was added propan2amine (285 mg, 483 mol, 7.00 eq.), and 3rd Generation BrettPhos pre catalyst (64 mg, 007 rnmoi, 0.10 eq.). After being purged with N2 for additional 2 miii, the resultingsolution was sealed and subjected to microwave reactor (120 C, 1.5 h). The reaction mixture was allowed to cool to rt and quenched with H20 After removal of the volatiles under reduced pressure, the residue was redissoIved in DMSO, filtered and subjected to reverse preparative HPLC Prep C18, 5 mM XBndge column, 19x 150 mm, waters gradient elution of i025% MeCN in water over a 10 mm period, where both solvents contain 0.1% trifluoroacetic acid (TF A)) to provide the titlecompound as brown oil (70 ing, 15%). LCMS (ES) [[M+1]f m/z384.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Ming; LI, Zhe; (206 pag.)WO2018/119208; (2018); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5333-42-6, name is 2-octyldodecan-1-ol, the common compound, a new synthetic route is introduced below. Computed Properties of C20H42O

Example 7 Preparation of 2-octyldodecyl heptanoate To a 3-neck 1000 ml round-bottomed flask was added 2-octyl-1-dodecanol (250.0 g, 837.37 mmol, 1.0 equiv.), n-heptanoic acid (141.72 g, 1088.6 mmol, 1.30 equiv.), toluene (250 ml) and p-toluenesulfonic acid monohydrate (1.5929 g, 8.374 mmol, 0.010 equiv.) at room temperature. The resulting mixture was heated at reflux with stirring in an oil bath at 134 C. under a nitrogen atmosphere for 18 hours. The water produced in the reaction was collected in a Dean-Stark trap. The cooled mixture was diluted with hexanes, washed with dilute aqueous 10% Na2CO3 solution, water, brine, dried (MgSO4), filtered, and concentrated in vacuo to afford a crude product. Excess solvent was further removed by heating the crude product with stirring in an oil bath under high vacuum for 3 hours to afford a light yellow liquid (326.7 g, 95%).

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ExxonMobil Research and Engineering Company; Ng, Man Kit; Oumar-Mahamat, Halou; Cheng, Hong; Blain, David A.; Cooper, Kathleen K.; Carey, James T.; Douglass, Michael R.; Kanga, Percy R.; Patil, Abhimanyu O.; Bodige, Satish; Lewis, Kyle G.; Hagemeister, Mark P.; (40 pag.)US2017/183595; (2017); A1;,
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Reference of 4415-82-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4415-82-1, name is Cyclobutylmethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.

Intermediate D: tert-butyl [(5i?,7S)-8-(cyclobutylmethyl)-l-(3-fluorophenyl)-7-methyl-2-oxo- l,3,8-triazaspiro[4.5]dec-3-en-4-yl]carbamate; To a solution of intermediate C (1.45 g, 3.85 mmol) and cyclobutane carboxaldehyde (0.97 g, 11.6 mmol prepared from alcohol using TPAP/NMO) in DCM (60 mL) at 0 0C was added NaHB(OAc)3 (1.23 g, 5.8 mmol). The mixture was allowed to slowly warm to rt and stir for 18h. The mixture was diluted with aq. NaHCO3 and DCM. The organic layer was isolated, washed sequentially with water and brine, dried with Na2SO4 and concentrated to dryness to give 2.6 g of crude material. Purification using automated SiO2 chromatography (MeOH/DCM) provided 1.5 g of desired tert-butyl [(5i?,7iS)-8-(cyclobutylmethyl)-l-(3-fluorophenyl)-7-methyl- 2-oxo-l,3,8-triazaspiro[4.5]dec-3-en-4-yl]carbamate as a white foam. LCMS (M+H) = 445.

Statistics shows that 4415-82-1 is playing an increasingly important role. we look forward to future research findings about Cyclobutylmethanol.

Reference:
Patent; MERCK & CO., INC.; WO2008/54698; (2008); A2;,
Alcohol – Wikipedia,
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Application of 873-76-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 873-76-7, name is (4-Chlorophenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: Reactants used were p-methylbenzyl alcohol (122.03g, 1000mmol, i.e., of formula (I) wherein R is methyl, n = 1, m = 0 , X = C),cuprous iodide (9.50 g of , 50mmol), N- phenylglycine (7.51g, 50mmol), TEMPO ( 7.80g, 50mmol),sodium hydroxide (4.00g, 100mmol), aqueous ammonia (300mL, 25 ~ 28%) ,ethanol, 800mL, in an ice bath under the condition, with oxygen round bottom flask is evacuated of air ventilation 3 times, and then the system was stirred at 25 , 24h, after completion of the reaction, the reaction solution was cooled to room temperature, rotary evaporated to remove the solvent, the residue was washed with water filtered and dried The product was 107.64g, yield 92%. The reaction was used for the chlorobenzyl alcohol (28.40g, 200mmol, i.e., of formula (I) wherein R is 4-chloro, X = C, n = 1 , m = 0), the same experimental methods and procedures of Example 2, except that: Cuprous iodide(1.90g, 10mmol), N- phenyl-phenylalanine (2.41g, 10mmol), TEMPO ( 1.56g, 10mmol), sodium hydroxide (0.80g, 20mmol), aqueous ammonia (60mL, 25 ~ 28%) , ethanol 160mL, under condition of 80 stirred for 24h, to give the final product 24.66g, yield 90%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,873-76-7, (4-Chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Zhang, Guofu; Zhang, Guihua; Ding, Chengrong; Li, Shasha; Xu, Shengjun; Shan, Shang; (9 pag.)CN105294646; (2016); A;,
Alcohol – Wikipedia,
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Electric Literature of 28539-02-8 ,Some common heterocyclic compound, 28539-02-8, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 4-nitroaniline ( 1.00 g, 7.2 mmol) and 1H-Benzotriazole-1-methanol (1.07 g, 7.2 mmol) in ethanol (25 mL) was stirred under reflux until the compounds was dissolved. After the reaction was stirred for 5 h at room temperature, it was stirred for 12 h at – 5 C. The residue was filtrated and washed with cold ethanol. This residue was added sodium borohydride (0.34 g, 8.99 mmol) in THF (20 mL) and stirred for 1 h under reflux. Then, after an ice water was poured into this reaction, the mixture was extracted with ether (3 x 30 mL). The combined organic layer was washed with brine (30 mL), dried over sodium sulfate, and concentrated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,28539-02-8, its application will become more common.

Reference:
Article; Uno, Masaharu; Koma, Yosuke; Ban, Hyun Seung; Nakamura, Hiroyuki; Bioorganic and Medicinal Chemistry Letters; vol. 22; 16; (2012); p. 5169 – 5173;,
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Reference of 56456-49-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56456-49-6, name is 4-Chloro-2-fluorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

a) 4-(4-Chloro-2-fluorobenzyloxy)pyridin-2(1H)-one A suspension of (4-chloro-2-fluorophenyl)methanol (3.24 g, 20.1 mmol), 2-chloro-4-iodopyridine (4.40 g, 18.3 mmol), Cs2CO3 (7.76 g, 23.8 mmol), CuI (3.48 g, 18.7 mmol) and 1,10-phenanthroline (659 mg, 3.66 mmol) in toluene (20 mL) was degassed by bubbling N2 through the suspension for 15 min. The suspension was put under N2 and heated at 105 C. for 18 h. The suspension was cooled, 9:0.9:0.1 CH2Cl2/MeOH/NH4OH (10 mL) was added, and the resulting suspension was passed through a plug of SiO2. The resulting solution was concentrated under reduced pressure. Flash chromatography on silica gel (hexanes/(1:1 EtOAc/hexanes), 100:0 to 0:100) afforded a white solid. A suspension of the white solid and NH4OAc (2.66 g, 34.6 mmol) in 1:1 HCO2H/H2O (20 mL) was heated at reflux with stirring for 4 d. The solution was cooled and concentrated under reduced pressure. The resulting residue was made basic with saturated NaHCO3 solution, and the resulting suspension was filtered. The solid was washed with H2O and CH2Cl2, and dried under reduced pressure to afford 1.28 g (28%) of the title compound as a white solid: 1H NMR (300 MHz, DMSO-d6) delta 11.14 (br s, 1H), 7.59 (dd, J=8.1, 8.1 Hz, 1H), 7.52 (dd, J=10.2, 1.8 Hz, 1H), 7.36 (dd, J=8.1, 1.8 Hz, 1H), 7.25 (d, J=7.2 Hz, 1H), 5.89 (d, J=7.2, 2.4 Hz, 1H), 5.83 (d, J=2.4 Hz, 1H), 5.06 (s, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56456-49-6, 4-Chloro-2-fluorobenzyl alcohol.

Reference:
Patent; ALBANY MOLECULAR RESEARCH, INC.; US2011/3793; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 6240-11-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6240-11-5, name is 1-Adamantaneethanol. This compound has unique chemical properties. The synthetic route is as follows.

1- Adamantane ethanol (4.758 g, 26.4 mmol, Aldrich, Milwaukee, WI) was added, and the sealed mixture was stirred overnight at room temperature. It was then poured into 10% NaHCO3 solution (50 mL) and the pyridine was evaporated under vacuum. The slightly yellow solid was dissolved in 1 L of water and extracted with ether (three 150 mL portions). The aqueous phase was acidified with 2 N HCl to pH 1, and then extracted with three 150 mL portions of CHCl3 :H-BUOH (7:3). The combined organic layer (ether and CHCl3 :w-BuOH) was washed with water and a slightly yellow precipitate was formed in the mixed solvents, at which point the solvents were evaporated under vacuum. A slightly yellow solid was formed and was recrystallized from acetone/hexane. The solid was dried under vacuum, yield 60 %

According to the analysis of related databases, 6240-11-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INSERT THERAPEUTICS, INC.; WO2006/89007; (2006); A2;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 329218-12-4, name is 3-Bromo-4-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromo-4-chlorobenzyl Alcohol

260 g (about 1.05 mol) of crude (3-bromo-4-chlorophenyl)methanol were dissolved in 2.86 litres of dichloromethane, the solution was cooled to -5 C. and 127.1 g (44.6 ml, 460 mmol) of phosphorus tribromide were added slowly. After the end of the addition, the mixture was stirred at -5 C. for another 1 h and then diluted with diluted with dichloromethane and water. The organic phase was removed, dried over magnesium sulphate and concentrated under reduced pressure. This gave, as a crude product, 280.5 g (about 84% of theory) of 2-bromo-4-(bromomethyl)-1-chlorobenzene. [0432] GC-MS (Method 1): Rt=5.36 min; m/z=281/283/285 (M+H)+. [0433] 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=4.71 (s, 2H), 7.49 (dd, 1H), 7.63 (d, 1H), 7.89 (d, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol.

Reference:
Patent; Lampe, Thomas; Hahn, Michael; Stasch, Johannes-Peter; Schlemmer, Karl-Heinz; Wunder, Frank; El Sheikh, Sherif; Li, Volkhart Min-Jian; Becker-Pelster, Eva Maria; Stoll, Friederike; Knorr, Andreas; US2015/152050; (2015); A1;,
Alcohol – Wikipedia,
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