Month: May 2021

Related Products of 6351-10-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6351-10-6, name is 2,3-Dihydro-1H-inden-1-ol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirring mixture of the substrate (1 mmol) and RiHA (0.08 g) in CH3CN (3 mL),HMDS (0.75 mmol, 0.120 g) was added at room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was filtered and the residue was washed with acetonitrile (5 mL). Evaporation of the solvent gave almost pure product(s). Further purification was carried out by bulb-to-bulb distillation under reduced pressure or recrystallization to afford pure silyl ether(s).

According to the analysis of related databases, 6351-10-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shirini; Akbari-Dadamahaleh, Somayeh; Mohammad-Khah, Ali; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; 5; (2014); p. 577 – 586;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 355-80-6 ,Some common heterocyclic compound, 355-80-6, molecular formula is C5H4F8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Glucose (9 g, 0.05 mol), 1-octafluoropentanol (116 g, 0.5 mol) and a catalyst (3.6 g) were placed in a glass reactor. The mixture was stirred for 5 h at 100 C under 200 Torr pressure. The unreacted glucose and the catalyst were separated by filtration, and the reaction products were obtained as a solution in fluoroalcohol. The alcohol was distilled off under reduced pressure on a rotary evaporator.Then 100 mL of water was added to the concentrated products and the remaining fluoroalcohol was removed as an azeotrope. In this way, the water solution of glucoside (containing 20% of non-volatile residue) was prepared. Next, the products were dried to give a pale-green viscous oil and analyzed by the GC/MS method. Analysis was performed using a HP 6890 series GC system (Hewlett-Packard, Palo Alto, CA, USA) equipped with a MSD detector (HP 5973 Network). A 30 m capillary column with 0.2 mm diameter, modified with HP-5M methylphenylsilicone, was used for separation of the reaction products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nowicki, Janusz; Mokrzycki, ?ukasz; Sulikowski, Bogdan; Molecules; vol. 20; 4; (2015); p. 6140 – 6152;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1346674-69-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1346674-69-8, name is (2,6-Dibromo-4-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 104m 2,6-Dibromo-4-fluorobenzyl Acetate 104m To a solution of (2,6-dibromo-4-fluorophenyl)methanol (1041) (20 g, 71 mmol) in CH2Cl2 (500 mL) at 0 C. was added pyridine (8.4 g, 107 mmol) and acetyl chloride (8.3 g, 107 mmol). The mixture was stirred at room temperature for 5 h. TLC showed the start material disappeared. The reaction was evaporated in vacuum and the residue was purified by silica-gel column chromatography eluting with petroleum ether/ethyl acetate (from 50:1 to 20:1) to give 104m as a white solid (20 g, 87%). MS: [M-Oac]+ 267. 1H NMR (500 MHz, CDCl3) delta 7.36 (d, J=7.5, 2H), 5.38 (s, 2H), 2.10 (s, 3H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1346674-69-8, (2,6-Dibromo-4-fluorophenyl)methanol.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Young, Wendy B.; US2013/116245; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

General procedure: Using diaryl acetylenesA 5-mL two-necked flask equipped with a stir bar was charged with [RhCl(cod)]2 (0.0125 mmol,6.16 mg), BINAP (0.0125 mmol, 7.78 mg), 1a-c (0.25 mmol), KI (0.25 mmol, 41.5 mg), and Na2CO3(1.0 mmol, 106.0 mg). The central neck of the flask was equipped with a reflux condenser havinga N2 gas-bag (2 L), which was connected by a three-way stopcock at its top, and a rubber septumwas inserted i n to the side neck. The flask was evacuated and backfilled with N2 (three times).Xylene (1.0 mL), 2a (0.75 mmol, 161.3 mg), and furfural (1.75 mmol, 168.2 mg), were then added.After degassing the reaction mixture three times by the freeze-pump-thaw method, the flask wasfilled with N2. The mixture was placed in an oil bath that had been preheated to 140 C for 20 h.After cooling to room temperature, the resulting solution was filtered through a pad of celite, andthe filtrate was concentrated in vacuo. The resulting crude product was purified by flash columnchromatography on silica-gel to afford 3aa-3ac.

Statistics shows that 7073-69-0 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)propan-2-ol.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 5182-44-5 ,Some common heterocyclic compound, 5182-44-5, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Dissolved e1 – e3 (1.0 equiv) completely in dry DMF, then added NaH (2.2 equiv) to the reaction slowly at 0 C and the resulting mixture was stirred for 20 minutes, and then corresponding R2(CH2)nOH or g1 – g5 (1.2 equiv) was added and the reaction mixture was stirred for 1 h at room temperature. Then it was quenched by H2O, washed with brine and extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was purified by chromatography on a silica gel chromatography (petroleum ether/ ethyl acetate = 8:1 to 4:1) to give corresponding products h1 – h22 (yield 75% – 89%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5182-44-5, 2-(3-Chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cheng, Kai; Li, Shiyu; Lv, Xiao; Tian, Yongbin; Kong, Haiyan; Huang, Xufeng; Duan, Yajun; Han, Jihong; Xie, Zhouling; Liao, Chenzhong; Bioorganic and Medicinal Chemistry Letters; vol. 29; 8; (2019); p. 1012 – 1018;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 6338-55-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6338-55-2 as follows.

To a 1 L three-necked flask, 23.5 g of a compound BP103a03 (1.0 eq), 68.6 g (Boc)2O (2.0 eq), and a mixture of methanol and triethylamine (9:1) (500 ml) were added, and the mixture was stirred and refluxed for 1 h. After completion of the reaction was monitored by TLC, methanol was evaporated triethylamine, dissolved in water and extracted three times with dichloromethane, and the combined organic layers were washed with water once, dried over anhydrous sodium sulfate, the solvent was distilled off, and dried to give a solid BP103a04 of 34.8g

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.

Reference:
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; Huang Yangqing; Song Yunsong; (20 pag.)CN109771658; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7541-49-3, blongs to alcohols-buliding-blocks compound. COA of Formula: C20H40O

Product obtained by hydrogenating phytol. [1234] To a solution of phytol (30.00 g, 101.20 mmol) in THF (450 mL) in argon is added platinum dioxide (PtO2, 1.15 g, 6.61 mmol). The medium is placed under 1 bar of dihydrogen then stirred for 4 h at ambient temperature. After filtering on celite by rinsing with THF, a black oil of molecule 47 is obtained after concentration at reduced pressure. [1235] Yield: 29.00 g (96%) [1236] 1H NMR (CDCl3, ppm): 0.84 (6H); 0.86 (6H); 0.89 (3H); 1.00-1.46 (22H); 1.46-1.68 (3H); 3.61-3.73 (2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7541-49-3, its application will become more common.

Reference:
Patent; ADOCIA; CHAN, You-Ping; GEISSLER, Alexandre; NOEL, Romain; ROGER, Walter; CHARVET, Richard; LAURENT, Nicolas; (75 pag.)US2019/275156; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

EXAMPLE 84-(4-Fluorobenzyloxy)- 1-[4-(3 -hydroxy-3 -methylbutoxy)-3 -methoxyphenyl]pyridin-2-( lH)-oneTo a solution of 4-[(4-fluorobenzyloxy)-l-(4-hydroxy-3-methoxyphenyl) pyridin-2(lH)- one (25 mg, 0.073 mmol), 3-methylbutane-l, 3-diol (11 mg, 0.11 mmol) and triphenylphosphine (19 mg, 0.073 mmol) in anhydrous THF (0.5 mL) under N2 atmosphere at 0C, diisopropyl azodicarboxylate (14 mg, 0.080 mmol) was added. After stirring at rt overnight, the volatiles were removed under reduced pressure, and the residue was purified with preparative HPLC eluting with water /acetonitrile (containing 0.1%TFA, 37 % to 67 %) to afford the title compound. 1HNMR (400MHz, CDC13, delta ppm): 7.39-7.53 (3H, m), 7.12 (2H, t, J= 8.8Hz), 7.04-7.09 (IH, m), 6.88-6.97 (IH, m), 6.78-6.86 (IH, m), 6.20-6.28 (IH, m), 6.05-6.09 (IH, m), 5.12 (2H, s), 4.12- 4.21 (2H, m), 3.84 (3H, s), 1.99 (2H, t, J= 6.8 Hz), 1.26 (6H, s). LCMS: m/e 428 [M+H]+.

According to the analysis of related databases, 2568-33-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIN, Linus; SOLL, Richard; DONG, Jingchao; WU, Hao; SUZUKI, Takao; HU, Bin; LIU, Dejun; HAO, Jinglai; XU, Ming; WO2011/127643; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 627-27-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

To a suspension of 8.0 g NaH (333.32 mmol, 60 % w/vdispersion in mineral oil, 4.0 eq) in 100 cm3, anhydrousTHF was added drop wise to a solution of 6.0 g 3-buten-1-ol 8 (83.33 mmol, 1.0 eq) at 0 C. To this mixture, 0.150 gTBAI and 11.9 cm3 benzyl bromide (99.99 mmol, 1.2 eq)were added, and stirring was continued for 2 h at the sametemperature and overnight at 25 C. The reaction mixturewas quenched by small crushed ice flakes until a clearsolution (biphasic) had formed. The reaction mixture wasextracted with ether and the extract was washed with water(1 9 100 cm3), brine (1 9 100 cm3) and dried over anhydrousNa2SO4. Evaporation of the solvents followed bycolumn chromatography (silica gel, 60-120 mesh, 5 %EtOAc in pet. ether) afforded the pure product 9 (12.2 g,91 % yield) as a colorless liquid.

Statistics shows that 627-27-0 is playing an increasingly important role. we look forward to future research findings about But-3-en-1-ol.

Reference:
Article; Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Hatti, Islavathu; Venkata Basaveswara Rao, Mandava; Raju, Rudraraju Ramesh; Monatshefte fur Chemie; vol. 146; 11; (2015); p. 1921 – 1926;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate P1082-phenyl-4,6-dihydro-2H-furo [3 ,4-c]pyrazol-31006951 Step A: Preparation of 4-oxotetrahydrofuran-3-carbonitrile: To a suspension of KOtBu (996.6 mg, 8.88 1 mmol) in THF (640.4 mg, 8.88 1 mmol) cooled to 0 C was added dropwise methyl 2-hydroxyacetate (675.7 jiL, 8.881 mmol) and stirred for 10 minutes. The acrylonitrile (589.1 jiL, 8.881 mmol) was then added and the reaction stirred at ambient temperature. After 3 hours, the reaction was diluted with 1120 (50 mL), then extracted with Et20 (25 mL) to remove any starting ester. The basic aqueous phase was acidified with 2M HC1 (5 mL), then extracted with Et20 (2 x 50 mL). The combined organic phases were dried with MgSO4, filtered, and concentrated to afford a light brown oil (446 mg, 45.2% yield). ?H NMR (CDC13) 4.63 (t, 111), 4.24 (t, 111), 4.14 (d, 1H), 4.02 (d, 1H), 3.57 (t, 111).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96-35-5, Methyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; BLAKE, James F.; BRANDHUBER, Barbara J.; HAAS, Julia; NEWHOUSE, Brad; THOMAS, Allen A.; WINSKI, Shannon L.; WO2014/78331; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts