Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 172023-97-1, name is (3-Bromo-5-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 172023-97-1

3-(Hydroxymethyl)-5-(trifluoromethyl)benzonitrile. (3-Bromo-5-(trifluoromethyl)phenyl)methanol (1.4 g, 5.5 mmol), tetrakis(triphenylphosphine) palladium(0) (0.64, 0.55 mmol) and zinc cyanide (388 mg, 3.31 mmol) were combined in dimethylformamide (6 mL). The reaction mixture degassed repeatedly using the freeze-thaw method. After warming to room temperature, the reaction was heated at 90 C. for 1 h, cooled to room temperature and concentrated. The crude product was dissolved in ethyl acetate, washed with water (2×), 1 N hydrochloric acid (2×), brine (2×), dried over sodium sulfate, and concentrated. Flash chromatography on silica gel gave 0.37 g (33%). LC/MS (HPLC method 3): tR=2.06 min, 202.02(MH)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 172023-97-1, (3-Bromo-5-(trifluoromethyl)phenyl)methanol.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/249607; (2007); A1;,
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Reference of 4728-12-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4728-12-5 as follows.

Example 492-Nitro-6-f4-(4-trifluoromethoxy-phenyl)-piperazin-1-ylmethyl1-6,7-dihvdro-5H-imidazof2,1- b1H .31oxazine (53)Pyridinium chlorochromate (10.54 g, 48.9 mmol) is dissolved in dichloromethane (100 ml) and celite (10 g) is added and the suspension is stirred for 30 minutes. A solution of (2,2- dimethyl-1 ,3-dioxan-5-y.)rpiethanol (5 g, 34.2 mmol) in dry dichloromethane is added drop wise to the reaction mixture and stirred for 2h at room temperature. The reaction mixture is diluted with diethyl ether (80 ml), stirred for 10 minutes, filtered through celite, washed several times with ether and the solvent is removed in vacuo to give crude 2,2-dimethyl- [1,3]dioxane-5-carbaldehyde, which is used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; US DEPARTMENT OF HEALTH & HUMAN SERVICES; WO2007/75872; (2007); A2;,
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Related Products of 30379-58-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The benzyl glycolate or thiobenzyl glycolate (1.5 equivalent) was added to the stirred suspension of peracetobromo-alpha-D-glucose, mannose, galactose (1 equivalent) and indium tribromide (10-15 mol%) in anhydrous dichloromethane (2 mL) at room temperature for an hour. The progress of reaction was monitored with thin layer chromatography. After the completion of the reaction, the reaction mixture was diluted with water and quenched with 10% aqueous acidic acid solution (1 mL). The organic layer washed with water and brine, the solvent was evaporated under reduced pressure and the crude product was purified by flash column chromatography on silica gel (90% ethyl acetate/hexanes). The corresponding beta-carboxymethyl glucosides (beta-CMGL) were afforded in good yield with high anomeric selectivity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Article; Chandra, Sunena; Yadav, Ram N.; Paniagua, Armando; Banik, Bimal K.; Tetrahedron Letters; vol. 57; 13; (2016); p. 1425 – 1429;,
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Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 26021-57-8, blongs to alcohols-buliding-blocks compound. name: 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol

Compound 54 (36 mg, 0.24 mmol) was dissolved in a solution of z-PrOFl/FhO (9/1, 1 mL) at 80 C for 30 min. A suspended solution of 35 (52 mg, 0.25 mmol) and HCIO4 (70%, 25 pL) in 90% z-PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCh and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCh). The fractions containing product were pooled and evaporated, affording LGW-03-37 (27 mg, 32%) as a dark blue solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26021-57-8, its application will become more common.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; GIBBS, Summer L.; WANG, Lei G.; BARTH, Connor W.; (159 pag.)WO2020/23911; (2020); A2;,
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Synthetic Route of 140373-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4,6-dichloropyrimidine (240 mg, 1.61 mmol) and 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol (250.00 mg, 1.61 mmol) in isopropanol (3 mL) was added DIPEA (0.84 mL, 4.83 mmol). The solution was stirred for 5 h at 50 C. H2O (50 mL) was added to the cooled solution and extracted with 10% IPA/DCM (3×50 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated in vacuo to afford 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol compound 18 (365 mg, 85%) as thick yellow liquid. MS (ESI): Calcd. for C12H11ClFN3O: 267, found 268 (MH+).

According to the analysis of related databases, 140373-17-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346450; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-70-8, name is 2-Amino-2-ethylpropane-1,3-diol. A new synthetic method of this compound is introduced below., COA of Formula: C5H13NO2

(19-1) Synthesis of [1,1-bis(hydroxymethyl)propyl]carbamic acid t-butyl ester (compound 19-1) To a solution of 2-amino-2-ethyl-1,3-propanediol (22.0 g) in methanol (500 ml) and N,N-diisopropylethylamine (64.3 ml) was added di-t-butyl dicarbonate (60.5 g) under ice-cooling, and the mixture was stirred for 40 min under ice-cooling and further at room temperature for 16 hr. 1M aqueous sodium hydroxide solution (184 ml) was added to the reaction mixture under ice-cooling and the mixture was stirred for 40 min. Methanol was removed under reduced pressure. Water was added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (41.0 g) as a colorless oil. 1H-NMR(CDCl3)delta(ppm): 0.90(3H, t, J=7.5Hz), 1.45(9H, s), 1.59(2H, q, J=7.5Hz), 3.45(2H, brs), 3.60(2H, dd, J=6.9, 11.6Hz), 3.84(2H, dd, J=4.8, 11.6Hz), 4.89(1H, brs).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-70-8, 2-Amino-2-ethylpropane-1,3-diol.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1961734; (2008); A1;,
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Application of 506-43-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 506-43-4, name is (9Z,12Z)-Octadeca-9,12-dien-1-ol, molecular formula is C18H34O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of methanesulfonic acid octadeca-9,12-dienyl ester 2To a solution of the alcohol 1 (26.6 g, 100 mmol) in dichloromethane (100 mL), triethylamine (13.13 g, 130 mmol) was added and this solution was cooled in an ice-bath. To this cold solution, a solution of mesyl chloride (12.6 g, 110 mmol) in dichloromethane (60 mL) was added dropwise and after the completion of the addition, the reaction mixture was allowed to warm to ambient temperature and stirred overnight. The TLC of the reaction mixture showed the completion of the reaction. The reaction mixture was diluted with dichloromethane (200 mL), washed with water (200 mL), satd. NaHCO3 (200 mL), brine (100 mL) and dried (NaSO4). The organic layer was concentrated to get the crude product which was purified by column chromatography (silica gel) using 0-10% Et2O in hexanes. The pure product fractions were combined and concentrated to obtain the pure product 2 as colorless oil (30.6 g, 89%). 1H NMR (CDCl3, 400 MHz) delta=5.42-5.21 (m, 4H), 4.20 (t, 2H), 3.06 (s, 3H), 2.79 (t, 2H), 2.19-2.00 (m, 4H), 1.90-1.70 (m, 2H), 1.06-1.18 (m, 18H), 0.88 (t, 3H). 13C NMR (CDCl3) delta=130.76, 130.54, 128.6, 128.4, 70.67, 37.9, 32.05, 30.12, 29.87, 29.85, 29.68, 29.65, 29.53, 27.72, 27.71, 26.15, 25.94, 23.09, 14.60. MS. Molecular weight calculated for C19H36O3S, Cal. 344.53. Found 343.52 (M-H-).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 506-43-4, (9Z,12Z)-Octadeca-9,12-dien-1-ol.

Reference:
Patent; Tekmira Pharmaceuticals Corporation; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil G.; Eltepu, Laxman; Ansell, Steven; Chen, Jianxin; US9186325; (2015); B2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 756520-66-8

A slurry of l-(2,6-dichloro-3-fluorophenyl)ethanol (4.6 g, 22 mmol) and P2O5 (17.5 g, 0.12 mol) in DCM (200 mL) was stirred at rt for 16 hours. The solid was filtered off through a pad of CELITE, and washed with DCM (200 mL) for several times. The filtrate was washed with saturated Na2C03 aqueous solution (100 mL x 2). The separated organic layer was dried over anhydrous Na2S04, and concentrated in vacuo. The white solid precipitated during concentration was discarded. The remained oil was dried in vacuo, and used directly in the next step without further purification (3.5 g, 83%). MS (ESI, pos. ion) m/z: 191.0 (M+l); 1H NMR (400 MHz, DMSO- e): delta 7.60-7.50 (m, 1H), 7.45-7.35 (m, 1H), 6.75-6.63 (m, 1H), 5.90-5.75 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Xiaobo; WO2014/193647; (2014); A2;,
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Electric Literature of 186020-66-6 , The common heterocyclic compound, 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, molecular formula is C13H26O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Tosyl chloride (22.3 g, 117 mmol) was added in portions to a stirring solution of 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester (16.3 g, 58.6 mmol) and pyridine 60 mL in (240 mL) and the mixture was stirred overnight. The reaction was quenched with water (300 mL) and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (2*100 mL). The combined organic layer was washed with HCl (1N, 100 mL), water (100 mL), and dried over Na2SO4 and the solvent was removed in vacuo to give an oil which corresponds to the title compound that would be used as is for the next step. (M+1)=433.

The synthetic route of 186020-66-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bradshaw, Curt; Bhat, Abhijit; Lai, Jing Yu; Doppalapudi, Venkata; US2008/166364; (2008); A1;,
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Related Products of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

Procedure 1, Step A. To a solution of 2-(4-aminophenyl)-l, l,l,3,3,3-hexafluoropropan-2- ol (4) (15 g, 1.0 equiv) in DMF (120 mL) was added a solution of NaN02(4.4 g, 1.1 equiv) in 30 mL water. The mixture was cooled to 0C for 15 min. 6 N HC1 (29 mL, 3.0 equiv) was added dropwise to the reaction mixture for over 15 min at 0C. The resulting mixture was stirred at 0C for lh. KI (10.1 g, 1.05 equiv) was added with portions (over 15 mins). The reaction mixture was stirred at 0C for lh, and then at room temperature overnight. The reaction was diluted with water (-500 mL) and extracted with EtOAc/hexane (2: 1, 3 x 150 mL). The combined organic phase was washed with NaHS03, water, and brine. The crude mixture was purified on a silica gel column to afford l, l,l,3,3,3-hexafluoro-2-(4-iodophenyl)propan-2-ol (Intermediate 1) (18.85 g, yield 88%) as a pale yellow oil.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ESCALIER BIOSCIENCES B.V.; MOHAN, Raju; NUSS, John; HARRIS, Jason; YUAN, Shendong; (144 pag.)WO2019/177996; (2019); A1;,
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