Related Products of 3344-77-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, molecular weight is 265.23, as common compound, the synthetic route is as follows.
General procedure: To a stirred solution of the 1,12-dodecanediol (5) (1.00 equiv) in30 mL of toluene HBr 48% (2.00 equiv) was added. The reaction wasstirred at 110C for 24 h. The solvent was removed under reducedpressure, and the residue was purified by column chromatographyover silica gel, eluting with hexane/EtOAc 9:1, to yield pure haloalcohol (6). This compound was transformed into their corresponding azidoalcohol (7) via classic SN2 substitution. A stock solution of 0.5 M NaN3in DMSO was prepared by stirring the solutionfor 24 h at room temperature. To a 100 mL round-bottom flaskequipped with a magnetic stir bar was added a 0.5 M solution ofNaN3in DMSO at room temperature. To this solution was added thebromo alcohol (6) (1.00 equiv) and the mixture was stirred for 24 hat room temperature. The reaction was quenched with H2O (50 mL)and stirred until it cooled to room temperature. The mixture wasextracted with Et2O(330 mL), and the resultant extracts werewashed with H2O(350 mL) and brine (50 mL). The organic layerwas dried (Na2SO4) and filtered, and the residue obtained waspurified by column chromatography over silica gel, eluting withhexane/EtOAc 9:1, to yield pure alkyl azidoalcohol (7).
The chemical industry reduces the impact on the environment during synthesis 3344-77-2, I believe this compound will play a more active role in future production and life.
Reference:
Article; Gontijo, Vanessa Silva; Espuri, Patricia Ferreira; Alves, Rosemeire Brondi; De Camargos, Luiz Fernando; Dos Santos, Fabio Vieira; De Souza Judice, Wagner Alves; Marques, Marcos Jose; Freitas, Rossimiriam Pereira; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 24 – 33;,
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