Adding a certain compound to certain chemical reactions, such as: 50595-15-8, tert-Butyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 50595-15-8, blongs to alcohols-buliding-blocks compound. Product Details of 50595-15-8
A solution of 2-te/f-butyl glycolate (437 mg; 3.31 mmol) in anhydrous THF (5 ml.) was treated with NaH (159 mg; 3.97 mmol) and stirred at RT for 10 minutes before treating with a solution of 3-bromo-2,5-dichloropyridine (Matrix; 500 mg; 2.20 mmol) in anhydrous THF (5 ml_). The resulting reaction mixture was stirred for 22 hours. The reaction mixture was treated with a solution of 2-te/f-butyl glycolate (437 mg; 3.31 mmol) in THF (2 ml), then with NaH (159 mg; 3.97 mmol) and the reaction mixture was stirred for 16 h. The reaction was quenched with tBuOH, the sovent removed under reduced pressure affording a brown solid, which was purified by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc, affording the title compound as a yellow sticky solid.1H NMR (300MHz, DMSOd6) delta [ppm] 8.33 (1 H, d, J= 2.3 Hz), 8.21 (1 H, d, J= 2.3 Hz), 4.86 (2H, s), 1.38 (9H, s). HPLC (Condition A) Rt 5.1 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,50595-15-8, its application will become more common.
Reference:
Patent; MERCK SERONO S.A.; CROSIGNANI, Stefano; JORAND-LEBRUN, Catherine; CLEVA, Christophe; PRETRE, Adeline; WO2010/92043; (2010); A1;,
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