The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H7BrO3
To a stirred solution of (6-bromo-1,3-benzodioxol-5-yl)methanol (1.27 g, 5.50 mmol) in THF (45.0 ml.) was added n-BuLi (5.00 ml_, 2.0 M, 10.0 mmol) dropwise at -75 0C. The reaction mixture was stirred at -75 0C for 45 min followed by the addition of a solution of 1-pentyl-1/-/-indole-2,3-dione (1.00 g, 4.60 mmol) in THF (20.0 ml.) at -75 0C. The resulting mixture was stirred at ambient temperature for 12 hrs and quenched with ammonium chloride solution (5.00 ml_). More ethyl acetate and water were added and separated. The organic layer was concentrated in vacuo to dryness. The residue was subjected to column chromatography eluting with 50% EtOA?Hexanes to yield the title compound (0.29 g, 25%) as a solid: 1H NMR (300 MHz, CDCI3) delta 7.38-7.24 (m, 2H), 7.11 (t, 1 H), 6.91 (d, 1 H), 6.81 (s, 1 H), 6.43 (s, 1 H), 5.90-5.87 (m, 2H), 4.77 (dd, 2H), 3.75-3.56 (m, 2H), 1.75-1.58 (m, 2H), 1.26-1.35 (m, 2H), 0.89-0.83 (m, 3H); 13C NMR (75 MHz, CDCI3) delta 177.8, 147.4, 147.2, 142.8, 133.5, 132.2, 131.1 , 130.1 , 125.3, 123.8, 111.4, 109.2, 108.1 , 101.5, 79.5, 64.7, 40.4, 29.0, 26.8, 22.3, 13.9; MS (ES+) m/z 352.1 (M – 17).
With the rapid development of chemical substances, we look forward to future research findings about 6642-34-8.
Reference:
Patent; XENON PHARMACEUTICALS INC.; WO2006/113864; (2006); A2;,
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