Synthetic Route of 59854-12-5 ,Some common heterocyclic compound, 59854-12-5, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of tert-butyl-4-hydroxybutyrate (24, 100 mg, 0.62 mmol) in EtOAc (5 mL) was added CDI (101 mg, 0.62 mmol) and the reaction mixture was stirred for 3 h. Amine hydrochloride 20 (285 mg, 0.62 mmol) was added to the reaction mixture and the reaction was refluxed for 22 h. Upon cooling to rt the solvent was evaporated and the resultant residue was purified by column chromatography (silica-gel, gradient 10-20% EtOAc in petroleum ether) to afford impure ter/-butylester 25 (140 mg) as yellow oil: 1H NMR (CDCl3, 400 MHz) delta 8.36 (d , J = 8.8 Hz, 2H), 7.96 (d, J= 8.8 Hz, 2H), 7.34-7.22 (m, 5H), 4.77-4.76 (m, IH), 4.03-3.97 (m, 2H), 3.85-3.82 (m, IH), 3.20-3.17 (m, 2H), 3.02-2.87 (m, 2H), 2.38-2.34 (m, 2H), 2.24-2.18 (m, 2H), 1.89-1.82 (m, 3H), 1.46 (s, 9H), 0.91-0.87 (m, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59854-12-5, its application will become more common.
Reference:
Patent; AMPLYX PHARMACEUTICALS, INC.; MUTZ, Mitchell; BARR, Kenneth, J.; GESTWICKI, Jason; WO2010/77317; (2010); A2;,
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