Adding a certain compound to certain chemical reactions, such as: 495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol, blongs to alcohols-buliding-blocks compound. Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol
General procedure: General procedure for preparation of benzyl bromides from benzaldehydes: To a stirring solution of aldehyde (1.0 equiv) in methanol (0.2 M) was added sodium borohydride (2.0 equiv.). The resulting solution was stirred at RT for 30-60 mins, until no precipitate was evident in solution and flask was cool to the touch. Solvent was removed in vacuo and dichloromethane introduced. Organic layer was washed using water, dried over sodium sulfate, filtered and solvent removed in vacuo to yield crudebenzyl alcohol, which was used without further purification. To a stirring solution of benzyl alcohol (1.0 equiv.) in dry dichloromethane (0.1 M) at 0 C was added phosphorus tribromide (1.1 equiv.). The reaction solution was stirred at 0 00 for 30 mins, quenched with water, transferred to a separating funnel and the organic layer washed with water. Combined organic layers were dried over sodium sulfate, filteredand solvent removed in vacuo to yield crude benzyl bromide, which was used without purification in catalytic Wittig reactions. o Br 5-(Bromomethyl)-1,3-benzodioxole was prepared inaccordance with the general procedure. 1,3-Benzodioxol-5-o – ylmethanol was prepared in 88% yield (2.68 g, 17.6 mmol) fromthe reaction of piperonal (3.00 g, 20 mmol, 1 .0 equiv.) and sodium borohydride (1 .51 g,40 mmol, 2.0 equiv.). Upon reaction with phosphorus tribromide (1.82 mL, 19.4 mmol,1.1 equiv.), 5-(bromometh/l)-1,3-benzodioxole was obtained as a white solid in 85%yield (3.54 g, 16.5 mmol). H NMR (400 MHz, CDCI3) 6: 3.84 (s, 3H), 3.87 (s, 6H), 4.47(s, 2H), 6.62 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.
Reference:
Patent; DUBLIN CITY UNIVERSITY; O’BRIEN, Christopher; WO2014/140353; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts