Synthetic Route of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.
tbcadpnHCOOH (200 mg, 0.3 mmol) was dissolved in methanol (25 mL). Acetic acid (75 pL), glycolaldehyde dimer (50 mg, 0.4 mmol) and 5-ethyl-2-methylpyridine borane (80 pL, 0.5 mmol) were successively added. The clear solution was stirred for 3 days at ambient temperature. The solvent was removed and the residue purified via preparative HPLC (018 column, solvent: water + 0.1 wt% formic acid (A) I acetonitrile (B); gradient:from 15 % B to 55 % B in 15 minutes; UV detection at 232 nm). The combined product fractions were lyophilized. The residue (50 mg) was suspended in 6 M hydrochloric acid (100 mL), heated to reflux for 3 hours and stirred for 12 hours at rt afterwards. The solution was evaporated to dryness. The remaining solid was dissolved in 0.5 M hydrochloric acid (5 mL) and sorbed on DOWEX 50. The column was washed with water(0.5 L) and 0.5 M hydrochloric acid (1 L) and the product was eluted with 3 M hydrochloric acid (1.5 L). The eluant was removed and the solid dried in vacuo to yield 40 mg H2tacidphe3H ClxH2O.1H-NMR (300 MHz, D20, pH* = 0): 6 = 2.99 (t, 4H), 3.44 (m, 2H), 3.57 (t, 4H), 3.78 (m,3H), 3.97 (m, 2H), 4.76 (m, 3H) ppm.
According to the analysis of related databases, 23147-58-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BERGER, Markus; SUeLZLE, Detlev; FRENZEL, Thomas; GRAHAM, Keith; JOST, Gregor; NEIS, Christian; HEGETSCHWEILER, Kaspar; PIETSCH, Hubertus; WO2014/173857; (2014); A1;,
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