Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 10488-69-4, blongs to alcohols-buliding-blocks compound. Recommanded Product: 10488-69-4
In a three-necked flask, 200 mL of tetrahydrofuran and 19 g of diisopropylamine were added and cooled to -10 ° C. 134 mL of n-butyllithium was added slowly while keeping the temperature, and the mixture was stirred for 30 minutes. The internal temperature of the reactor was maintained at -40 to -30 , 36 mL of tert-butyl acetate was slowly added dropwise, and the mixture was stirred for 1 hour while maintaining the temperature of the reaction solution. (S) -ethyl 4-chloro-3-hydroxybutanoate was added dropwise at -40 to -30 ° C for 30 minutes and stirred for 30 minutes. The inner temperature of the reaction solution was raised naturally to -20 to -10 ° C The reaction was then completed by further stirring for 2 hours. When the reaction is complete, waterAnd the reaction was quenched. To the reaction solution was added 300 mL of ethyl acetate. The reaction mixture was stirred for 30 minutes to extract the product. The organic layer was extracted and separated. The organic layer was treated with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure The obtained oily product (12.3 gr) was obtained.
The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nebula Pharma PVT. LTD; Jang, Myung Sik; Jang, Rae Kyu; Mo, Gil Wung; Jung, In Hwa; Lee, In Kyu; Han, Ka Ram; (25 pag.)KR101528359; (2015); B1;,
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