As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C13H12O2
Manufacturing Example 28-1: 1-Chloromethyl-3-phenoxy-benzene To a solution of carbon tetrachloride (40 mL) of (3-phenoxy-phenyl)-methanol (2.0 g) was added triphenylphosphine (3.2 g) at room temperature, which was heated to reflux under a nitrogen atmosphere for 5 hours and 40 minutes. The reaction mixture was cooled to room temperature and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate = 10:1) to obtain the titled compound (2.1 g). 1H-NMR spectrum (DMSO-d6) 8 (ppm): 4.37 (2H, s), 6.94-6.97 (1H, m), 7.00-7.03 (2H, m), 7.05-7.06 (1 H, m), 7.13-7.20 (3H, m), 7.37-7.41 (2H, m).
With the rapid development of chemical substances, we look forward to future research findings about 13826-35-2.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065377; (2009); A1;,
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