Adding a certain compound to certain chemical reactions, such as: 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, blongs to alcohols-buliding-blocks compound. name: (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol
The monobenzalpentaerythritol (5.00 g, 22.3 mmol), (3.5) 12G1-C02H (4b) (24.07 g, 49.05 mmol), and DPTS (5.90 g, 22.3 mmol) were dissolved in anhydrous CH2C12 (120 mL). DCC (1 1.96 g, 57.97 mmol) dissolved in anhydrous CH2C12 (20 mL) was added and the reaction was stirred for 12 h. at room temperature under nitrogen atmosphere. After the reaction was complete, the mixture was diluted, filtered, and rinsed with Et20. The solvent was removed and the crude product was purified by column chromatography (Si02, 5% Et20:hexane) and followed by precipitation in MeOH to give a white solid as a product: 25.29 g (97%). XH NMR (500 MHz, CDC13) delta 7.55 – 7.46 (m, 2H, PhH-3, 5), 7.41 – 7.34 (m, 3Eta, PhH-2, 4, 6), 7.12 (d, J= 2.3 Hz, 2H, ArH-2, 6), 7.1 1 (d, J= 2.2 Hz, 2H, ArH-2′, 6′), 6.64 (t, J= 2.2 Hz, 1H, ArH-4), 6.62 (t, J= 2.2 Hz, 1H, ArH-4′), 5.52 (s, 1Eta, CH-acetal), 4.82 (s, 2Eta, ArC02CH2), 4.33 (d, J= 11.8 Hz, 2H, 20CHaHb-ring), 4.26 (s, 2H, ArC02CH2), 4.03 (d, J= 11.8 Hz, 2H, 20CHaHb-ring), 3.98 – 3.90 (m, 8Eta, 4ArOCH2), 1.81 – 1.73 (m, 8Eta, 4ArOCH2CH2), 1.48 – 1.40 (m, 8Eta, 4ArOCH2CH2CH2), 1.26 (m, 64Eta, 4(CH2)8CH3), 0.88 (t, J= 6.9 Hz, 12H, 4CH3). 13C NMR (126 MHz, CDC13) delta 166.3 (C=0), 166.2 (C=0′), 160.4 (ArC-3, 5), 160.3 (ArC-3 ‘, 5’), 137.8 (PhC-1), 131.7 (PhC-3, 5), 131.2 (PhC-4), 129.4 (PhC-2, 6), 128.5 (ArC-1), 126.3 (ArC-1 ‘), 107.89 (ArC-2, 6), 107.85 (ArC-2′, 6′), 106.81 (ArC-4), 106.5 (ArC- 4′), 102.4 (CH-acetal), 69.9 (OC-ring), 68.52 (ArOCH2), 68.49 (ArOCH2′), 64.2 (ArC02CH2), 63.5 (ArC02CH2’), 38.0 (C(CH20)4), 32.1 (CH2CH2CH3), 29.82, 29.79, 29.76, 29.73, 29.6, 29.5, 29.3, 26.2 (ArOCH2CH2CH2), 22.8 (CH2CH3), 14.3 (CH3). The spectroscopic data of 16b are in agreement with those previously reported.
The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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