Application of 929-06-6 ,Some common heterocyclic compound, 929-06-6, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Di-tert-butyl dicarbonate (4.973 g, 22.8 mmol) in CHC13 (100 mL) was added dropwise to a solution of 2-(2-aminoethoxy)ethanol (2.4 mL, 22.8 mmol) in CHCI3 (100 mL) and stirred o/n. Water was added and the layers separated. The aqueous layer was extracted once with CH2CI2. The combined organics were dried (MgS04), filtered, and concentrated to provide the title compound. 1H NMR (CDCI3) delta 4.95 (br s, 1 H), 3.78-3.70 (m, 2H), 3.60-3.52 (m, 4H), 3.38-3.28 (m, 2H), 2.22 (br s, 1H), 1.45 (s, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,929-06-6, its application will become more common.
Reference:
Patent; MYREXIS, INC.; HOLCOMB, Ryan; SUZUKI, Kazuyuki; HALTER, Robert J.; SEBAHAR, Paul R.; MCLEOD, Donald A.; SHENDEROVICH, Mark D.; YAGER, Kraig M.; BURSAVICH, Matthew Gregory; YUNGAI, Ashantai J.; RICHARDS, Burt; BARTEL, Paul L.; WETTSTEIN, Daniel A.; WO2011/46970; (2011); A1;,
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