Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 26021-57-8, blongs to alcohols-buliding-blocks compound. name: 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
Compound 54 (36 mg, 0.24 mmol) was dissolved in a solution of z-PrOFl/FhO (9/1, 1 mL) at 80 C for 30 min. A suspended solution of 35 (52 mg, 0.25 mmol) and HCIO4 (70%, 25 pL) in 90% z-PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCh and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCh). The fractions containing product were pooled and evaporated, affording LGW-03-37 (27 mg, 32%) as a dark blue solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26021-57-8, its application will become more common.
Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; GIBBS, Summer L.; WANG, Lei G.; BARTH, Connor W.; (159 pag.)WO2020/23911; (2020); A2;,
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