Synthetic Route of 140373-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 4,6-dichloropyrimidine (240 mg, 1.61 mmol) and 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol (250.00 mg, 1.61 mmol) in isopropanol (3 mL) was added DIPEA (0.84 mL, 4.83 mmol). The solution was stirred for 5 h at 50 C. H2O (50 mL) was added to the cooled solution and extracted with 10% IPA/DCM (3×50 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated in vacuo to afford 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol compound 18 (365 mg, 85%) as thick yellow liquid. MS (ESI): Calcd. for C12H11ClFN3O: 267, found 268 (MH+).
According to the analysis of related databases, 140373-17-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346450; (2018); A1;,
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