Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To THF (2 mL) in microwave reaction vessel were added ethanol (0.059 mL, 1.0 mmol) and sodium hydride (32 mg, 1.3 mmol). After stirring for 30 min at room temperature, 2,6-dichloropyrazine (100 mg, 0.671 mmol) was added to the reaction mixture. The reaction mixture was heated in the microwave reactor at power 100 W and 50 C for 10 min. After solvents were removed under reduced pressure, the residue was dissolved in ethyl acetate. Organic layer was washed with water and dried over MgSO4.
According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; More, Kunal N.; Jang, Hyo Weon; Hong, Victor S.; Lee, Jinho; Bioorganic and Medicinal Chemistry Letters; vol. 24; 11; (2014); p. 2424 – 2428;,
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