Related Products of 7218-43-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7218-43-1 as follows.
Weigh 200mg of 1-adamantanacetic acid, dissolve it in 3mL of dichloromethane, add DCC, DMAP successively under ice bath, stir for 30min under ice bath, add 156mg of intermediate 6, The reaction was performed at room temperature for 5 hours. After the reaction was detected to be complete by LC-MS, the insoluble matter was removed by filtration, and dichloromethane (20 mL x 3) was added. Extracted twice with 20 mL of saturated sodium bicarbonate, dried by adding anhydrous MgSO4 for 5 h, filtered with suction, and purified by column chromatography under reduced pressure to obtain 180 mg of intermediate H-1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.
Reference:
Patent; Zhengzhou University; Ke Yu; Xie Hang; Liu Hongmin; Xu Xia; Liang Jianjia; (25 pag.)CN110759897; (2020); A;,
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