Reference of 57772-50-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57772-50-6, name is (2-Amino-3-methylphenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.
EXAMPLE 13 2-Amino-3-methylbenzyl alcohol (1.7 g.) and anhydrous chloral (2.4 ml.) were mixed for 10 minutes with external ice-cooling, and the mixture was left to stand for 1/2 hour. The mixture was then chromatographed on silica, and elution with diethyl ether/petroleum ether (b.p. 60-80 C.), 7:3 by volume, gave 1,2-dihydro-8-methyl-2-trichloromethyl-4H-benzo[d]-[1,3]-oxazine, which was crystallized from aqueous ethanol, m.p. 69-70 C. The process described above was repeated, using the appropriate o-aminobenzyl alcohol as starting material, to give the following analogous products:
The chemical industry reduces the impact on the environment during synthesis 57772-50-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Imperial Chemical Industries Limited; US4268510; (1981); A;,
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