With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, molecular weight is 184.23, as common compound, the synthetic route is as follows.Application In Synthesis of [1,1′-Biphenyl]-4-ylmethanol
General procedure: To a flask that was charged with the benzyl alcohol (10 mmol), triethylamine (20 mmol) in THF (25 mL) cooled at 0 C, was added mesyl chloride (20 mmol) in THF (50 mL) over half an hour. Then the mixture was allowed to stir at room temperature for about 20-30 min. Cold water was added to the mixture, then the mixture was extracted with diethyl ether (125 mLx1). Triethylamine (5 mol) was added into the crude product solution to remove the unreacted mesyl chloride. Then the solution was washed with saturated aqueous NaHCO3 (10 mL), cold water (25 mL) and brine (25 mL). The solution was dried over anhydrous Na2SO4. Removal of the solvent under reduced pressure gave the benzyl mesylate products, which are used in the coupling reaction without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, and friends who are interested can also refer to it.
Reference:
Article; Wu, Guojiao; Xu, Shuai; Deng, Yifan; Wu, Chaoqiang; Zhao, Xia; Ji, Wenzhi; Zhang, Yan; Wang, Jianbo; Tetrahedron; vol. 72; 49; (2016); p. 8022 – 8030;,
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