Synthetic Route of 627-27-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.
To a suspension of 8.0 g NaH (333.32 mmol, 60 % w/vdispersion in mineral oil, 4.0 eq) in 100 cm3, anhydrousTHF was added drop wise to a solution of 6.0 g 3-buten-1-ol 8 (83.33 mmol, 1.0 eq) at 0 C. To this mixture, 0.150 gTBAI and 11.9 cm3 benzyl bromide (99.99 mmol, 1.2 eq)were added, and stirring was continued for 2 h at the sametemperature and overnight at 25 C. The reaction mixturewas quenched by small crushed ice flakes until a clearsolution (biphasic) had formed. The reaction mixture wasextracted with ether and the extract was washed with water(1 9 100 cm3), brine (1 9 100 cm3) and dried over anhydrousNa2SO4. Evaporation of the solvents followed bycolumn chromatography (silica gel, 60-120 mesh, 5 %EtOAc in pet. ether) afforded the pure product 9 (12.2 g,91 % yield) as a colorless liquid.
Statistics shows that 627-27-0 is playing an increasingly important role. we look forward to future research findings about But-3-en-1-ol.
Reference:
Article; Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Hatti, Islavathu; Venkata Basaveswara Rao, Mandava; Raju, Rudraraju Ramesh; Monatshefte fur Chemie; vol. 146; 11; (2015); p. 1921 – 1926;,
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