Electric Literature of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.
EXAMPLE 84-(4-Fluorobenzyloxy)- 1-[4-(3 -hydroxy-3 -methylbutoxy)-3 -methoxyphenyl]pyridin-2-( lH)-oneTo a solution of 4-[(4-fluorobenzyloxy)-l-(4-hydroxy-3-methoxyphenyl) pyridin-2(lH)- one (25 mg, 0.073 mmol), 3-methylbutane-l, 3-diol (11 mg, 0.11 mmol) and triphenylphosphine (19 mg, 0.073 mmol) in anhydrous THF (0.5 mL) under N2 atmosphere at 0C, diisopropyl azodicarboxylate (14 mg, 0.080 mmol) was added. After stirring at rt overnight, the volatiles were removed under reduced pressure, and the residue was purified with preparative HPLC eluting with water /acetonitrile (containing 0.1%TFA, 37 % to 67 %) to afford the title compound. 1HNMR (400MHz, CDC13, delta ppm): 7.39-7.53 (3H, m), 7.12 (2H, t, J= 8.8Hz), 7.04-7.09 (IH, m), 6.88-6.97 (IH, m), 6.78-6.86 (IH, m), 6.20-6.28 (IH, m), 6.05-6.09 (IH, m), 5.12 (2H, s), 4.12- 4.21 (2H, m), 3.84 (3H, s), 1.99 (2H, t, J= 6.8 Hz), 1.26 (6H, s). LCMS: m/e 428 [M+H]+.
According to the analysis of related databases, 2568-33-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIN, Linus; SOLL, Richard; DONG, Jingchao; WU, Hao; SUZUKI, Takao; HU, Bin; LIU, Dejun; HAO, Jinglai; XU, Ming; WO2011/127643; (2011); A1;,
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