With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, molecular weight is 75.1097, as common compound, the synthetic route is as follows.Application In Synthesis of 2-(Methylamino)ethanol
2-(methylamino)ethanol (3.8 ml), 46.9 mmole) was dissolved in DCM (200 ml) and triethylamine (15 ml, 107 mmole) was added. The solution was cooled to 0 C., a solution of 4-methoxy-2,6-dimethylbenzene-1-sulfonyl chloride (10 g, 42.6 mmole) dissolved in DCM (100 ml) was added, and the whole was stirred for 1.5 hours at RT. After completion of the reaction HCl (0.5 M, 100 ml) was added, the phases were separated, washed with water, dried over Na2SO4 and concentrated by evaporation. The crude product was used without further purification in the next stage. Yield 12.2 g, >100%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,109-83-1, 2-(Methylamino)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; GRUENENTHAL GmbH; US2009/186899; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts