Extended knowledge of 1805-32-9

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 1805-32-9, Adding some certain compound to certain chemical reactions, such as: 1805-32-9, name is 3,4-Dichlorobenzyl alcohol,molecular formula is C7H6Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1805-32-9.

Example 32; (3,4-Dichlorophenyl)methyl 2-cyanopyrazolidine-1 -carboxylate (32)(3,4-Dichlorophenyl)methyl chloroformate was prepared by dissolving 3,4-dichlorobenzyl alcohol (122.0 mg, 0.69 mmol) was in 3 mL dichloromethane followed by diisopropylethylamine (145 uL, 0.83 mmol). 20% Phosgene in toluene (473 uL, 0.83 mmol) was added dropwise and the reaction mixture was allowed to stir at room temperature for 2 hours. 4 was prepared according to Example 4. To this was added the 3,4- (dichlorophenyl)methyl chloroformate in one portion and the reaction mixture was stirred overnight at room temperature. After removal of solvent by rotary evaporation, the title EPO compounalpha was purified by silica gel chromatography (CombiFlash, 20% ethyl acetate in hexanes to 100% ethyl acetate over 10 minutes.) The appropriate fractions were collected, combined and evaporated to dryness to yield 32 (57.9 mg, 28.0%), ESMS 300.4 (M+H+).

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/94003; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts