Related Products of 6850-39-1 ,Some common heterocyclic compound, 6850-39-1, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of I [3 4.ch1oro.8methoxy- I H,2H,3 Wcyc1openta[ciquinolin7yl }oxy)propyl}pyrroiidine (Intermediate Wi) (250 mg, 0.69 mmoi, 100 eq.), i,4-dioxane (5 ml.), and t-l3uONa (331 mg, 3.45 mmol, 500 eq.) in a microwave reaction vial was purged with N2 for 5 mm. To the solution was added propan2amine (285 mg, 483 mol, 7.00 eq.), and 3rd Generation BrettPhos pre catalyst (64 mg, 007 rnmoi, 0.10 eq.). After being purged with N2 for additional 2 miii, the resultingsolution was sealed and subjected to microwave reactor (120 C, 1.5 h). The reaction mixture was allowed to cool to rt and quenched with H20 After removal of the volatiles under reduced pressure, the residue was redissoIved in DMSO, filtered and subjected to reverse preparative HPLC Prep C18, 5 mM XBndge column, 19x 150 mm, waters gradient elution of i025% MeCN in water over a 10 mm period, where both solvents contain 0.1% trifluoroacetic acid (TF A)) to provide the titlecompound as brown oil (70 ing, 15%). LCMS (ES) [[M+1]f m/z384.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.
Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Ming; LI, Zhe; (206 pag.)WO2018/119208; (2018); A1;,
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