Electric Literature of 149965-40-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. A new synthetic method of this compound is introduced below.
Step 2: ((5 -bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane A solution of (5 -bromo-2- chlorophenyl)methanol (3.80 g, 17.2 mmol), tert-butylchlorodimethylsilane (2.84 g, 18.9 mmol), and 1H-imidazole (2.34 g, 34.3 mmol) in DMF (30 mL) was maintained with stirring at 10 C for 16 hours. Then the reaction mixture was poured into diethyl ether (10 mL) and washed three times with 5% LiC1 (15 mL). The organic layer was separated, dried over sodium sulfate, filtered, taken toa residue under reduced pressure. The residue was purified by column chromatography (Si02, petroleum ether= 100%) to give the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,149965-40-2, (5-Bromo-2-chlorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHEN, Helen; COLLETTI, Steven, L.; DEMONG, Duane; GUO, Yan; MILLER, Michael; NAIR, Anilkumar; PLUMMER, Christopher, W.; XIAO, Dong; YANG, De-Yi; (289 pag.)WO2016/22742; (2016); A1;,
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