Electric Literature of 28539-02-8 ,Some common heterocyclic compound, 28539-02-8, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of 4-nitroaniline ( 1.00 g, 7.2 mmol) and 1H-Benzotriazole-1-methanol (1.07 g, 7.2 mmol) in ethanol (25 mL) was stirred under reflux until the compounds was dissolved. After the reaction was stirred for 5 h at room temperature, it was stirred for 12 h at – 5 C. The residue was filtrated and washed with cold ethanol. This residue was added sodium borohydride (0.34 g, 8.99 mmol) in THF (20 mL) and stirred for 1 h under reflux. Then, after an ice water was poured into this reaction, the mixture was extracted with ether (3 x 30 mL). The combined organic layer was washed with brine (30 mL), dried over sodium sulfate, and concentrated.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,28539-02-8, its application will become more common.
Reference:
Article; Uno, Masaharu; Koma, Yosuke; Ban, Hyun Seung; Nakamura, Hiroyuki; Bioorganic and Medicinal Chemistry Letters; vol. 22; 16; (2012); p. 5169 – 5173;,
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