The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1,3-Diaminopropan-2-ol
To a solution of 3-1 (3.00 g, 33.3 mmol) in dichloromethane (300 mL) was added triethylamine (5.10 mL, 36.6 mmol), 4-dimethylaminopyridine (DMAP, 40.7 mg, 0.333 mmol), and tert-butyldiphenylsilyl chloride (TBDPSCI, 9.13 mL, 35.0 mmol), and the mixture was stirred at room temperature for 5 hours. The solvent was removed by concentration in vacuo and chromatographed by flash chromatography on silica gel (chloroform/methanol = 5: 1) to give 3-2 (8.28 g, 76%). 1H MR (400 MHz, CDC13): delta 1.08 (s, 9H), 2.70-2.79 (m, 4H), 3.60-3.63 (m, 1H), 7.36-7.45 (m, 6H), 7.67-7.70 (m, 4H). MS (CI+) m/z: 329 (MH+).
With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.
Reference:
Patent; MERCK SHARP & DOHME CORP.; INTERVET INTERNATIONAL B.V.; KYORIN PHARMACEUTICAL CO. LTD.; SINGH, Sheo B.; WARRASS, Ralf; ULLRICH, Joachim; KAWASHIMA, Mikako; FUKUDA, Yasumichi; TAKANO, Hisashi; (92 pag.)WO2016/123146; (2016); A1;,
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