Reference of 928-51-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 928-51-8, name is 4-Chlorobutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of DMSO (10ml) taken in a round bottom flask was added KOH (2equiv) and the solution was stirred at room temperature for 15min. The indole derivative 2 or 20 (1equiv) was then added and the mixture was further stirred for 1h, after which 4-chlorobutan-1-ol or 3-chloropropan-1-ol (1.5equiv) was added dropwise to the reaction mixture. The reaction was monitored by TLC to completion within 5h. The reaction mixture was then quenched by adding water and was extracted with ethyl acetate. Evaporation of the solvent under reduced pressure followed by column chromatography gave the required N-alkylated compounds, 3/13/21. 4.3.1 1-(4-Hydroxybutyl)-1H-indole-3-carbaldehyde (3) White solid (85%); mp 12 75-77 C.
According to the analysis of related databases, 928-51-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Naik, Prajakta N.; Khan, Ayesha; Kusurkar, Radhika S.; Tetrahedron; vol. 69; 50; (2013); p. 10733 – 10738;,
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