Related Products of 52273-77-5, Adding some certain compound to certain chemical reactions, such as: 52273-77-5, name is 2-(3-Aminophenyl)ethanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52273-77-5.
(28B) Methyl trans-4-{[3-(2-hydroxyethyl)phenyl]amino}cyclohexanecarboxylate [0325] 2-(3-Aminophenyl)ethanol (4.45 g, 32.4 mmol) produced in (28A), ethyl 4-cyclohexanonecarboxylate (5.52 g, 32.4 mmol), and acetic acid (18.5 mL, 324 mmol) were dissolved in tetrahydrofuran (100 mL), and sodium triacetoxy borohydride (13.8 g, 64.9 mmol) was added thereto, and then, the resulting mixture was stirred at room temperature for 4 hours. To the reaction solution, water was added, and the organic matter was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate and filtered. Then, the solvent was distilled off under reduced pressure, whereby a crude product was obtained. The obtained crude product was purified by silica gel column chromatography (hexane:ethyl acetate = 70:30 to 45:55 (v/v)), whereby the target compound was obtained as a colorless oil (1.93 g, yield: 19%). 1H NMR(CDCl3, 400MHz): delta1.09-1.21(2H, m), 1.26(3H, t, J=7.2Hz), 1.51-1.65(2H, m), 2.01-2.10(2H, m), 2.16-2.24(2H, m), 2.29(1H, tt, J=3.6, 12.1Hz), 2.78(2H, t, J=6.5Hz), 3.25(1H, tt, J=3.6, 11.2Hz), 3.40-3.59(1H, brs), 3.84(2H, q, J=6.0Hz), 4.14(2H, q, J=7.2Hz), 6.41-6.49(2H, m), 6.55(1H, d, J=7.4Hz), 7.11(1H, t, J=7.6Hz).
According to the analysis of related databases, 52273-77-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Daiichi Sankyo Company, Limited; TODA, Narihiro; TAKANO, Rieko; SHIDA, Takeshi; KATAGIRI, Takahiro; IWAMOTO, Mitsuhiro; ASHIDA, Shinji; YAMAZAKI, Mami; EP2623492; (2013); A1;,
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