In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. name: 1-(2,6-Dichloro-3-fluorophenyl)ethanol
Dissolve triphenylphosphine (17.50g, 66.73mmol) in THF,Argon protection, injection under ice bathDEAD (10.57mL, 66.73mmol),Add 1-(2,6-dichloro-3-fluorophenyl)ethanol (9.30g, 44.49mmol)And m-bromophenol (5.19mL, 48.94mmol) in THF,Move to room temperature and react overnight. TLC monitors the reaction is complete,The solvent was distilled off under reduced pressure,Separation and purification by silica gel column chromatography (petroleum ether / dichloromethane =200: 1, v / v) to obtain a transparent oil (8.51g, yield 52.84%).
The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Chinese Academy Of Sciences Shanghai Life Sciences Institute; Liu Hong; Yang Chenghua; Li Chunpo; Sun Chenxia; Liang Xuewu; Gao Yang; Shi Yuqiang; Zhao Sen; Jiang Hualiang; Chen Kaixian; (34 pag.)CN110950807; (2020); A;,
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