Electric Literature of 18068-06-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18068-06-9, name is 4-Methoxycyclohexanol. A new synthetic method of this compound is introduced below.
XXXXXVIII.2 4-Fluoro-2-(cis-4-methoxy-cyclohexyloxy)-phenylamine and 4-Fluoro-2-(trans-4-methoxy-cyclohexyloxy)-phenylamine A mixture of 18.9 g 2-nitro-5-fluorophenol and 19 g 4-methoxycyclohexanol in 250 ml THF were placed in a water bath with cold water. 41 g DTAD and 47 g triphenylphosphine were added simultaneously. The reaction mixture was stirred for 2 hours at room temperature. 1.9 g Pd/C (10%) were added and the reaction mixture hydrogenated (50 psi hydrogen) at room temperature for 20 hours. The mixture was filtered and concentrated. Methylene chloride was added to the residue and the mixture was extracted two times with HCl (2M). The water phase were adjusted to basic pH by addition of aq. sodium hydroxide solution (4M) and extracted two times with methylene chloride. The combined organic phases were dried over sodium sulfate, filtered and concentrated. Purification was achieved by column chromatographie on silica (eluent: methylene chloride/EtOAc=9:1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18068-06-9, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/217311; (2011); A1;,
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