Related Products of 2615-15-8 ,Some common heterocyclic compound, 2615-15-8, molecular formula is C12H26O7, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of hexaethylene glycol (2.99 g, 10.6 mmol) in CH2CI2 (1 0 mL) were successively added tosyl chloride (2.22 g, 1 1.6 mmol 1.1 equiv), silver (I) oxide (3.68 g5 15,9 mmol, 1.5 equiv) and potassium iodide (0.352 g, 0.212 mmol, 0.2 equiv) at 0C. The mixture (0297) FontWeight=”Bold” FontSize=”10″ Besenius, P.; Cormaek, PAS,,: Ludlow, S.F.; Otto, 5,; Sherrington, D.C Chem. Cam rt. 2:008, 24, 2809-2811. ;’ Svedhem, S.; Hollander, C.A.; Shi, Kortradsson, P.; Uedherg, 8.; Svensson, S.CT. J. Org, Chem. 2001, 68, 4494-4503. was stirred for 25 mia at this temperature, then filtered through a pad of Ceiite (m. I cm), which was then rinsed with methanol. Upon removing ail vol aides in vacuo, the residue was purified by flash chromatography (CH2Cl2/MeOH 1 : 0 to 9 : 1 ) to afford S4 (3.70 g, 8.48 mmol, 80%) as a colorless oil. The spectroscopic data of S4 matched well those reported in literature.4 *H NMR (CD?, 500 MHz): 7.79 (d, J ::: 7.9 Hz, 2H), 7.34 id, /-=== 7. Hz, 2H), 4.16 (t, J 4.7 Hz, 2H), 3.76-3.52 ( , 22H), 2.44 (s, 3H). MS (ESI) [M+Naf: m z 459.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; YALE UNIVERSITY; MERCK SHARP & DOHME CORP.; SPIEGEL, David, A.; CHIRKIN, Egor; ROEMER, Terry; NANTERMET, Philippe; (89 pag.)WO2018/35424; (2018); A1;,
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