Application of 28539-02-8, Adding some certain compound to certain chemical reactions, such as: 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole,molecular formula is C7H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28539-02-8.
Step A: To a mixture of 5a (0.44 g, 2.0 mmol) and EtOH (9.0 mL)was added 1H-benzotriazole-1-methanol (0.30 g, 2.0 mmol). After stirring at room temperature overnight, the reaction mixture was concentrated in vacuo and the obtained residue was triturated with hexane. The resulting precipitate was collected by filtration to give N-(1H-Benzotriazol-1-ylmethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (0.59 g, 84%) as a brown solid. 1HNMR (CDCl3) d: 8.03 (1H, d, J = 8.2 Hz), 7.67 (1H, d, J = 8.2 Hz),7.62 (1H, dd, J = 7.4, 1.6 Hz), 7.44-7.40 (1H, m), 7.33-7.28 (2H,m), 7.09 (1H, t, J = 7.2 Hz), 7.02 (1H, d, J = 8.2 Hz), 6.73 (1H, td,J = 7.4, 0.8 Hz), 6.16 (2H, d, J = 7.4 Hz), 1.37 (12H, s). MS (ESI-) m/z:349 (MH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 28539-02-8, 1-(Hydroxymethyl)benzotriazole, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ogiyama, Tomoko; Yamaguchi, Mitsuhiro; Kurikawa, Nobuya; Honzumi, Shoko; Yamamoto, Yuka; Sugiyama, Daisuke; Takakusa, Hideo; Inoue, Shin-ichi; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2234 – 2243;,
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