Reference of 52273-77-5 ,Some common heterocyclic compound, 52273-77-5, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2- (3-aminophenyl) ethanol (3. 01G, 21. 9mmol), acetone (53ml) and conc. HCl (9ml) was mixed and cooled to 0C. Sodium nitrite (1.86g, 21. 9MMOL) dissolved in 4ML water was added. The temperature was kept under 0C. After 1H methyl acrylate (18. 9g, 219. 4MMOL) was added and then Cu (I) I (0.42g, 2. 19MMOL) in portions. The mixture was stirred at room temperature over night. The acetone was evaporated and water was added. The water phase was extracted three times with ethyl acetate. The organic phases were pooled and washed (water, brine), dried (MGS04) and evaporated. The crude product was purified by flash chromatography using a 60: 40 mixture of ethyl acetate/toluene as eluent to yield 2.95g of the desired product (yield 55%). 1HNMR (400MHZ, CDC13) : 2. 85 (t, 2H), 3.16 (dd, 1H), 3.35 (dd, 1H), 3.74 (s, 3H), 3.85 (t, 2H), 4.45 (t, 1H), 7.05-7. 28 (M, 4H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52273-77-5, 2-(3-Aminophenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/113282; (2004); A1;,
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