Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. A new synthetic method of this compound is introduced below., Safety of (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol
To a solution of polymer bound triphenylphosphine (68 mg, 0.20 mmol, 3.0 mmol/g substitution) and carbon tetrabromide (68 mg, 0.20 mmol) in dry CH2Cl2 was added geranylgeraniol (56 muL, 0.17 mmol), and the reaction was stirred for 2 h. The polymeric reagent was removed by filtration and the solvents removed in vacuo. This crude product is stable overnight in the freezer, but was generally used directly in the Zn2+ catalyzed geranylgeranylation reactions after purification on a C18 SepPak column. The SepPak purification removes an unknown impurity that greatly increases the amount of undesirable disulfide peptide dimer formed instead of the desired geranylgeranylation of cysteine.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol.
Reference:
Article; Ochocki, Joshua D.; Mullen, Daniel G.; Wattenberg, Elizabeth V.; Distefano, Mark D.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 17; (2011); p. 4998 – 5001;,
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