Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4254-29-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 4254-29-9
2-hydroxy indan (100 g) was dissolved in 1,2-dichloroethane (400 ml) and added to thionyl chloride (125 g) slowly over a period of an hour. Temperature was maintained at less than 10 C. Thereafter, the reaction mass was slowly heated and refluxed till the completion of the reaction. The reaction was monitored by TLC. The reaction mass was cooled to room temperature and poured in to ice water, stirred for 1 hour and organic layer was separated. The aqueous layer was extracted with dichloroethane. Organic layers were combined and washed with water, sodium bicarbonate solution and dried over anhydrous sodium sulphate. Solvent was distilled out completely and the crude product was distilled under vacuum to obtain 2-chloroindan as a colorless liquid (118 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4254-29-9, 2,3-Dihydro-1H-inden-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; REDDY, G. Pratap; SUNKU, Venkataiah; BABU, Sunkaraneni Suresh; (14 pag.)US2018/215714; (2018); A1;,
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