Synthetic Route of 2807-30-9 , The common heterocyclic compound, 2807-30-9, name is 2-Propoxyethanol, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of the corresponding 4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-6-aryl-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-7(8H)-one (14{x}) (0.42mmol), Cs2CO3 (0.54mmol) and the corresponding alcohol (9mL) was heated a reflux overnight. The resulting solution was cooled down, water (100mL) was added and the reaction crude was neutralized with 2M HCl. The resulting solid was collected by filtration and washed with water, and EtOEt to afford the corresponding 15{x,y}. Starting from compound 14{5} and 2-propoxyethanol to afford 15{5,9} in 38% yield, white solid. IR (KBr), numax (cm-1): 3479, 3332, 3220, 2773, 1692, 1631, 1575, 1458, 1435, 1373, 777. 1H NMR (400 MHz, DMSO-d6): delta 10.51 (s, 1H, NH), 7.58-7.47 (m, 2H, C13-CH), 7.37 (t, J = 8.1 Hz, 1H, C14-CH), 6.42 (s, 2H, NH2), 4.63 (dd, J = 12.9, 9.2 Hz, 1H, C7-CH), 4.35-4.32 (m, 2H, C15-CH2), 3.63 (t, J = 4.9 Hz, 2H, C16-CH2), 3.35 (t, J = 6.6 Hz, 2H, C17-CH2), 2.93-2.79 (m, 2H, C6-CH2), 1.46 (h, J = 7.3 Hz, 2H, C18-CH2), 0.80 (t, J = 7.4 Hz, 3H, CH3). 13C NMR (100.6 MHz, DMSO-d6): delta 169.6, 166.4, 161.8, 158.0, 135.3, 135.1, 129.8, 128.3, 85.2 (C5), 71.9 (C17), 68.2 (C16), 65.0 (C15), 43.1 (C7), 22.4 (C18), 22.2 (C16), 10.4 (C19). Anal. Calcd. (%) for C18H20Cl2N4O2: C, 52.57; H, 4.90; N, 13.62. Found: C, 52.76; H, 5.12; N, 13.98.
The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Camarasa, Marta; De La Bellacasa, Raimon Puig; Gonzalez, Alex L.; Ondono, Rauel; Estrada, Roger; Franco, Sandra; Badia, Roger; Este, Jose; Martinez, Miguel Angel; Teixido, Jordi; Clotet, Bonaventura; Borrell, Jose I.; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 463 – 483;,
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