The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (4-Bromo-2,6-difluorophenyl)methanol
To a mixture of 4-bromo-2,6-difluorobenzyl alcohol (1.00 g, 4.48 mmol) in DCM (20 mL) is added Dess-Martin periodinane (2.12 g, 5.00 mmol). This mixture is stirred 2 h at RT. The mixture is then partitioned between EtOAc and sat. aq. NaHC03. The organic phase is washed with brine, dried over MgS04, filtered and concentrated. The crude product is purified by flash chromatography to afford aldehyde 14a1.
With the rapid development of chemical substances, we look forward to future research findings about 162744-59-4.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; STAMMERS, Timothy; BARBEAU, Xavier; BEAULIEU, Pierre; BERTRAND-LAPERLE, Megan; BROCHU, Christian; EDWARDS, Paul, J.; FORGIONE, Pasquale; GODBOUT, Cedrickx; HUCKE, Oliver; JOLY, Marc-Andre; LANDRY, Serge; LEPAGE, Olivier; NAUD, Julie; PESANT, Marc; POIRIER, Martin; POIRIER, Maude; THAVONEKHAM, Bounkham; WO2011/32277; (2011); A1;,
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