With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.Safety of 2-Cyclopropylethanol
EXAMPLE 172; 2-[9-(2-cyclopropylethoxy)-6-(2-hydroxy-2-methylpropyl)-leta-phenanthro[9,10-d]imidazol-2-yl]-5- fluoroisophthalonitrile; Step 1; 3-bromo-6-(2-cyclopropylethoxy)phenanthrene; To a mixture of 6-bromophenanthren-3-ol (3 g, 11 mmol) from Step 1 of Route A of Example 168, 2-cyclopropylethanol (2.85 g, 33 mmol) and triphenylphosphine (5.78 g, 22 mmol) in THF (50 mL) was added di-tert-butylazodicarboxylate (5.08 g, 22 mmol). The reaction mixture was stirred at room temperature overnight, then quenched with water. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried over MgSO4, filtered and concentrated. The material was purified by flash chromatography on silica (100% hexanes) to afford 3- bromo-6-(2-cyclopropylethoxy)phenanthrene.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2566-44-1, 2-Cyclopropylethanol, and friends who are interested can also refer to it.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2007/59610; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts