With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1736-74-9, name is 4-(Trifluoromethoxy)benzyl alcohol, molecular formula is C8H7F3O2, molecular weight is 192.1352, as common compound, the synthetic route is as follows.COA of Formula: C8H7F3O2
1-(Bromomethyl)-4-(trifluoromethoxy)benzene: To a solution of (4-(trifluoromethoxy)phenyl)methanol (3.6 g, 18.8 mmol) in CH2Cl2 (60 mL) was added PBr3 (6 g, 22.2 mmol) dropwise with stirring, while cooling to a temperature of 0-10 C. over a time period of 30 min. The resulting mixture was stirred at room temperature for 3 h. Water (30 mL) was added and the mixture washed with aqueous NaHCO3 (2×30 mL) and brine (30 mL). The organic solution was dried (Na2SO4) and concentrated in vacuo to afford the title compound (3.5 g, 66%) as a yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1736-74-9, 4-(Trifluoromethoxy)benzyl alcohol, and friends who are interested can also refer to it.
Reference:
Patent; KALYPSYS, INC.; US2007/270434; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts