Synthetic Route of 111-45-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-45-5, name is 2-(Allyloxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of alcohol 4A (5.1 g, 1.0 eq) in DCM (50 mL) cooled to 0 C was added a solution of Et3N (7 g, 1.4 eq) followed by dropwise addition of MsCl (6.9 g, 1.2 eq). The reaction was stirred at 0 C for 2 hrs. The reaction mixture was quenched with water and the organic layer was washed with NaHC03 (10 mL) and brine, dried over Na2S04. The crude mixture was filtered and evaporated under reduced pressure to afford the compound 4B, which was used for next step reaction without further purification.
According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; MA, Jingyuan; EMAYAN, Kumaraswamy; ADLER, Marc; (327 pag.)WO2018/9417; (2018); A1;,
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