Adding a certain compound to certain chemical reactions, such as: 69605-90-9, [1,1′-Biphenyl]-3-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
General procedure: Examples 9a-n were prepared in parallel fashion according to the following method. A stock solution of 8-chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine22 (0.9 M in toluene, 1 mL, 0.090 mmol) was added to a 2.0-5.0 mL microwave vial charged with the corresponding commercially available alcohol (0.648 mmol), cesium carbonate (50.0 mg, 0.153 mmol), 1,10-phenanthroline (20.0 mg, 0.111 mmol), and 20.0 mg of copper(I) iodide (20.0 mg, 0.105 mmol). The vials were sealed and heated to 100 C for 17 h. The reaction mixtures were cooled to rt, diluted with 0.5 mL of acetonitrile, and then filtered. The filtrates were concentrated in vacuo at 34 C for 1 h. Each sample was diluted with 0.5 mL of DMF (0.5 mL) and purified using reverse phase preparative LC-MS to afford the title product.
The synthetic route of 69605-90-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Higgins, Mendi A.; Marcin, Lawrence R.; Christopher Zusi; Gentles, Robert; Ding, Min; Pearce, Bradley C.; Easton, Amy; Kostich, Walter A.; Seager, Matthew A.; Bourin, Clotilde; Bristow, Linda J.; Johnson, Kim A.; Miller, Regina; Hogan, John; Whiterock, Valerie; Gulianello, Michael; Ferrante, Meredith; Huang, Yanling; Hendricson, Adam; Alt, Andrew; Macor, John E.; Bronson, Joanne J.; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 496 – 513;,
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