Adding a certain compound to certain chemical reactions, such as: 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
N, N-carbonyldiimidazole (5.36 g, 33 mmol) was added to a solution of N- (trifluoroacetyl) anthranilic acid (7.69 g, 33 mmol) prepared as described in Example 94 (1) above in tetrahydrofuran (80 ml) at room temperature with stirring under a nitrogen atmosphere, and-the resulting mixture was stirred for 1 hour. At the end-of this time, a solution of 2- (4-aminophenyl)-1, 1, 1, 3,3, 3-HEXAFLUORO-2-PROPANOL (5.70 g, 22 mmol) in tetrahydrofuran (60 ML) was added to the reaction mixture, and the resulting mixture was stirred at 70°C for 6 hours under the nitrogen atmosphere. The reaction mixture was then concentrated, poured into water and extracted twice with ethyl acetate (200 ML). The combined organic layers were washed successively with water (100 ml), 1N hydrochloric acid (100 ml), water (100 ml) and a saturated aqueous sodium chloride solution (100 ml) and dried over anhydrous sodium sulfate. The solvent was thus removed and the residue thus obtained was purified by silica gel column chromatography using a 5: 1 by volume mixture of hexane and ethyl acetate AS ELUANT to yield the title compound as a colorless solid (1.48 g, yield: 15percent). This product was recrystallized from a mixed solvent of hexane and ethyl acetate to yield colorless prisms. mp 183°C. IR (KBR) : SMAVc 3173,1670, 1373,1227, 1173,966 CM- . LH-NMR (400MHz, CDC13) : 8 8.34 (1H, d, J = 8.2 Hz), 7.91 (4H, M), 7.68 (1H, M), 7.42 (2H, d, J = 8.2 Hz), 3.86 (1H, s). FABMS (m/z): 457 ( [M+H] +). FABHRMS (m/z): calcd. for CLAHSFGN2ONA ([M+NA] +) : 479.0418 ; found: 479.0431. Anal. calcd. for C18H9F9N202 : C, 47.38 ; H, 1.99 ; N, 6.14 ; found : C, 46.98 ; H, 2.24 ; N, 6.54.
The synthetic route of 722-92-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANKYO COMPANY, LIMITED; X-CEPTOR THERAPEUTICS, INC.; WO2003/106435; (2003); A1;,
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