Electric Literature of 34231-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 205W-(3-(Hydroxymethyl)benzyl)-4-(2-(((frans)-4-acetamidocyclohexyl)methyl)-2W-tetrazol-5-yl)-6- methylpicolinamidelambda/,lambda/,lambda/’,lambda/’-Tetramethyl-O-(1/-/-benzotriotaazol-1-yl)uroniotaum hexafluorophosphate (159 mg, 0 42 mmol) was added to a mixture of 4-(2-((4-acetamiotadocyclohexyl)methyl)-2H-tetrazol-5-yl)-6- methylpicolinic acid (prepared as described in step 1 of the synthesis of 4-(2-(((frans)-4- acetamiotadocyclohexyl)methyl)-2/-/-tetrazol-5-yl)-lambda/-((6-hydroxypyriotadiotan-2-yl)methyl)-6-methylpiotacoliotanamiotade, Example 204) (50 mg, 0 14 mmol), (3-(amiotanomethyl)pheny.)methanol (prepared as described in step 1 of the synthesis of lambda/-(3-(hydroxymethyl)benzyl)-6-methyl-4-(2-(((/rans)-4-(methylsulfonamiotado)cydohexyl)methyl)-2H-tetrazol-5-yl)piotacoliotanamiotade, Example 183) (29 mg, 0 21 mmol), and triethylamine (0 03 mL, 0 21 mmol) in lambda/,lambda/-diotamethylformamiotade (2 mL) The mixture was stirred at room temperature for 18 hours The reaction mixture was purified by reverse phase preparative HPLC Fractions containing desired product were combined and concentrated The resulting residue was taken up in methanol and passed through a carbonate cartridge The filtrate was concentrated to afford the title compound as a solid (22 mg, 33%) MS (ES+) m/z 478 (M+H) 1H NMR (400 MHz, DMSO-d6) delta ppm 1 04 – 1 26 (m, 6 H), 1 56 – 1 67 (m, 2 H), 1 71 – 1 85 (m, 5 H), 1 91 – 2 03 (m, 1 H), 2 67 (s, 3 H), 3 25 – 3 35 (m, 1 H), 4 48 (s, 2 H), 4 54 (d, J=6 59 Hz, 2 H), 4 67 (d, J=I 32 Hz, 2 H), 7 14 – 7 34 (m, 3 H), 7 66 (d, J=I 32 Hz, 1 H), 8 08 (s, 1 H), 8 44 (s, 1 H), 9 22 (t, J=5 86 Hz, 1 H)
According to the analysis of related databases, 34231-22-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; WO2009/16498; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts