Electric Literature of 34598-50-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 34598-50-0, name is 5-Bromo-2,3-dihydro-1H-inden-1-ol. A new synthetic method of this compound is introduced below.
Step B: [(5-bromo-2,3-dihvdro-lH-inden-yl’)oxy]ft-butyl)dimethylsilane 5-bromoindan-l-ol (260 mg, 1.22 mmol) obtained in Step A was dissolved in methylene chloride (50 mL) and the mixture was cooled to 00C, followed by addition of trimethyldimethylsilyl trifluoromeihane sulfonate (355 mg, 1.34 mmol). After stirring for 30 min, the reaction temperature was elevated to room temperature. The reaction was terminated with addition of a saturated aqueous solution of ammonium chloride, followed by extraction with a 0.5N HCl aqueous solution. The organic layer was taken, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was directly used in subsequent reactions without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,34598-50-0, 5-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2009/38411; (2009); A2;,
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