Application of 229027-89-8, Adding some certain compound to certain chemical reactions, such as: 229027-89-8, name is 2-Bromo-4-fluorobenzyl Alcohol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 229027-89-8.
A mixture of (2-bromo-4-fluorophenyl)methanol (250g, 1.22 mol) and 3,4-dihydro-2H-pyran (205 g, 2.44 mol) is dissolved in DCM (2000 mL). To this solution is added pyridinium p-toluenesulfonate (15g, 0.06 mol). The resulting solution is stirred overnight at rt and then treated with saturated NaHC03. After extraction with EtOAc, the organic layer is washed with water and brine, dried, concentrated and purified by column chromatography over silica gel to provide the product of this step (281 g, yield 80%) as colorless oil.
According to the analysis of related databases, 229027-89-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ELI LILLY AND COMPANY; ANACOR PHARMACEUTICALS INC.; AKAMA, Tsutomu; JARNAGIN, Kurt; PLATTNER, Jacob J.; PULLEY, Shon Roland; WHITE, William Hunter; ZHANG, Yong-Kang; ZHOU, Yasheen; WO2014/149793; (2014); A1;,
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