Synthetic Route of 2173-69-5, Adding some certain compound to certain chemical reactions, such as: 2173-69-5, name is 2-Methyl-2-phenyl-1-propanol,molecular formula is C10H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2173-69-5.
A solution of 2-METHYL-2-PHENYLPROPAN-1-OL (160mg) (J. Org Chem 1982,47, 2476-2479) in DMF (8ml) under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 47mg) and the mixture stirred at 20 for 15min. (5R)-3-(6-Bromohexyl)-5-(2, 2- DIMETHYL-4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (400mg) was then added and the mixture was stirred at 20 for 5h. Phosphate buffer solution (pH 6.5, 15MOI) and water (15ml) were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). The solvent was evaporated in vacuo and the residue purified by flash chromatography on silica gel. Elution with ETOAC-PETROLEUM ether (1: 4) then (1: 2) gave an oil which was further purified by preparative thin layer chromatography on a silica plate (20 x 20cm). Elution with isopropyl acetate-toluene (2: 3) gave the title compound (100mg). LCMS RT = 3.92 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2173-69-5, 2-Methyl-2-phenyl-1-propanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/37768; (2004); A2;,
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