Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.3068-00-6, Name is 1,2,4-Butanetriol, SMILES is OCC(O)CCO, belongs to alcohols-buliding-blocks compound. In a document, author is Khan, Mohd Faheem, introduce the new discover, Category: alcohols-buliding-blocks.
3-Hydroxytyrosol regulates biofilm growth in Cunninghamella elegans
In contrast to yeast biofilms, those of filamentous fungi are relatively poorly understood, in particular with respect to their regulation. Cunninghamella elegans is a filamentous fungus that is of biotechnological interest as it catabolises drugs and other xenobiotics in an analogous manner to animals; furthermore, it can grow as a biofilm enabling repeated batch biotransformations. Precisely how the fungus switches from planktonic to biofilm growth is unknown and the aim of this study was to shed light on the possible mechanism of biofilm regulation. In dimorphic yeasts, alcohols such as tyrosol and 2-phenylethanol are known to control the yeast-to-hypha switch, and a similar molecule might be involved in regulating biofilm in C. elegans. Gas chromatography-mass spectrometry analysis of crude ethyl acetate extracts from supernatants of 72 h planktonic and biofilm cultures revealed 3hydroxytyrosol as a prominent metabolite. Further quantification revealed that the amounts of the compound in planktonic cultures were substantially higher (>10-fold) than in biofilm cultures. In the presence of exogenous 3-hydroxytyrosol the growth of aerial mycelium was inhibited, and there was selective inhibition of biofilm when it was added to culture medium. There was no biotransformation of the compound when it was added to 72 h-old cultures, in contrast to the related compounds tyrosol and 2-phenylethanol, which were oxidised to a number of products. Therefore, we propose that 3hydroxytyrosol is a new signalling molecule in fungi, which regulates biofilm growth. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of British Mycological Society.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 3068-00-6. Category: alcohols-buliding-blocks.
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts