Month: March 2021

Electric Literature of 57641-67-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57641-67-5, name is 2-(2-(2-Bromoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Potassium carbonate (916 mg, 6.6 mmol) was added to the solution of imidazole (375 mg, 5.5 mmol) and oligoethylene glycolic bromide (4a-e, 5.5 mmol) in acetone (30 mL) at 25 C. The residue was dissolved in water (50 mL) and extracted from the aqueous phase with EtOAc (50 mL¡Á3). The organic layer was dried (sodium sulfate) and evaporated under reduced pressure. The residue was purified by flash column chromatography (10% MeOH/CH2Cl2) to afford the corresponding oligoethylene glycolic imidazole (5a-e).

According to the analysis of related databases, 57641-67-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jadhav, Vinod H.; Kim, Ju-Young; Chi, Dae Yoon; Lee, Sungyul; Kim, Dong Wook; Tetrahedron; vol. 70; 2; (2014); p. 533 – 542;,
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Electric Literature of 100-37-8, Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol,molecular formula is C6H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8.

Valsartan 1.75 g (4.25 mmol),Dichloromethane 30mL,0.49 g (4.25 mmol) of 2- (diethylamino) ethanol was added to the reaction flask,After warming to reflux, 0.34 mL (4.25 mmol) of thionyl chloride,Reaction for 1 hour,HPLC detection reaction was complete,After treatment, the reaction mixture was evaporated to dryness under reduced pressure,Cooled to room temperature by adding 5mL of water,With sodium hydroxide solution to adjust pH = 9 ~ 10,Extract with 30 mL of dichloromethane,The combined organic layers were dried over anhydrous sodium sulfate,2.10 g of Compound (II) concentrated by filtration under reduced pressure were filtered off with a desiccant,Yield 92.5%.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kebeiyuan (Beijing) Bio-pharmaceutical Technology Co., Ltd.; Beijing Zhiyuan Technology Co., Ltd.; Liu Qi; Cheng Zengjiang; (46 pag.)CN107468685; (2017); A;,
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Electric Literature of 702-82-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 702-82-9, name is 3-Aminoadamantan-1-ol. A new synthetic method of this compound is introduced below.

Compound (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile (12.1 g, 70.3mmol) is added to dichloromethane (200mL), stir for 10 minutes, hydroxyl adamantanamine (12.7 g, 66.8mmol) is slowly added to the above solution, the resulting solution is stirred at room temperature for 10 minutes, Potassium carbonate (19. 3g, 140mmol) is added to the reaction solution, the reaction is stirred for 4 hours.The reaction solution has been filtered, the filter cake is washed with dichloromethane (50mL), combined filtrates. Rotate the solvent to get dryness, the residual oil is added to ethyl acetate to dissolve. The resulting ethyl acetate solution is washed with water (50mL X 2), dry over anhydrous sodium sulfate for 2 hours. The desiccant has been removed; and dried then obtained the crude compound 6 (21.2g).Vildagliptin crude (21. 2g) is added into the reactor which is containing 100mL 2-butanone. The mixture is heated to reflux (95 C) and stirred for 30 minutes. The mixture is filtered into a preheated (75 C) reactor; the filter cake is washed with using hot 2-butanone (100mL). The filtrate is heated to reflux for 30 minutes, slowly cool down at room temperature. Let stand overnight. The system is cooled with an ice water bath for 1 hour. The resulting suspension is filtered, the filter cake is washed twice with 2-butanone.The filter cake has been dried, and obtained target product Vildagliptin 12. 4g(white crystal), 61.3%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-82-9, its application will become more common.

Reference:
Patent; Shenzhen Hanyu Pharmaceutical Co., Ltd.; Liu Feimeng; Fang Yihua; Liu Jian; Ma Yaping; Yuan Jiancheng; (10 pag.)CN105884669; (2016); A;,
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Synthetic Route of 6214-44-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6214-44-4, name is (4-Ethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Under an argon stream, p-Ethoxybenzyl alcohol (1) (6.509, 42.7 mmol) Of anhydrous methylene chloride (90 mL), The mixed solution of anhydrous N, N-dimethylformamide (70 L) was cooled with ice, Thionyl chloride (4.0 mL, 55.7 mmol) was added, And stirred for 30 minutes. The reaction solution was concentrated and dissolved in tetrahydrofuran (30 mL) Was added dropwise to ice water (150 mL). It was extracted twice with methylene chloride (50 mL) The obtained organic layer was dried with sodium sulfate, By concentrating under reduced pressure, To give compound 2 (7.66 g) as a pale yellow liquid.

According to the analysis of related databases, 6214-44-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE; DOKKYO GAKUEN DOKKYO UNIVERSITY SCHOOL OF MEDICINE; MATSUMOTO, NOBUYUKI; ANZAI, NAOHIKO; (16 pag.)JP2018/62475; (2018); A;,
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Application of 100751-63-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, the compound obtained in the second step to the reactor (T-3) was charged (23.6 g, 99.6 mmol) and methylene chloride (250ml). The solution was cooled to 0 , and Dess-Martin periodinane; was added in portions (DMP 42.2g, 99.6mmol) to 3 times. The mixture was stirred for a further 2 hours while returning to room temperature. The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (300 ml), then was subjected to filtration, the filtrate was extracted with ethyl acetate. The organic layers were washed with water, aqueous sodium sulfite, and washed sequentially with water and saturated brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure, the residue was purified by silica gel chromatography (eluent: toluene) to give the compound (T-4) (19.05g, 81.0mmol; 81%) was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100751-63-1, 6-Bromo-2-naphthylmethanol.

Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; GOTO, MAYUMI; TANAKA, HIROYUKI; (104 pag.)JP2016/37458; (2016); A;,
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Related Products of 3840-31-1, Adding some certain compound to certain chemical reactions, such as: 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol,molecular formula is C10H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3840-31-1.

To the solution of 3,4,5-trimethoxybenzyl alcohol (7.2 g, 36.4 mol) in dry DCM (100 mL), thionyl chloride (3.5 mL, 48.2 mmol) and pyridine (3.4 mL, 42.1 mmol) were added dropwise. The reaction mixture was stirred at RT for 1.5 h and progress was monitored by TLC (AcOEt/Hex 1:1 as mobile phase). The reaction was stopped by the addition of 100 mL H2O and extracted with 2 x 25 mL DCM. The combined organic extracts were dried over MgSO4 and evaporated in vacuo to give 87% yield. Yellow, solid.

According to the analysis of related databases, 3840-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Urbaniak, Alicja; Delgado, Magdalena; Kacprzak, Karol; Chambers, Timothy C.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2766 – 2770;,
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Reference of 5259-98-3 , The common heterocyclic compound, 5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of Compound 13 To a solution of 5-chloro-l-pentanol (3.0 g, 24.47 mmol) Compound 11 in DMF (20 mL) was added sodium azide (1.909 g, 29.4 mmol) Compound 12. After being stirred at 60 ¡ãC for overnight, the reaction mixture was concentrated in vacu. The residue was purified by silica gel chromatography (EtOAc/Hexane 1 :3), to give product Compound 13 as clear liquid. 1H NMR (500 MHz, CDC13) delta 3.62 (m, 2H), 3.25 (t, J= 6.9 Hz, 2H), 1.63-1.53 (m, 4H), 1.45-1.40 (m, 2H).

The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TELLERS, David; COLLETTI, Steven, L.; DUDKIN, Vadim; AARONSON, Jeffrey; MOMOSE, Aaron; TUCKER, Thomas, Joseph; YUAN, Yu; CALATI, Kathleen, B.; TIAN, Lu; PARMAR, Rubina, G.; SHAW, Anthony, W.; WANG, Weimin; STORR, Rachel, Anne; BUSUEK, Marina; KOWTONIUK, Robert, A.; WO2013/166155; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6282-88-8, name is 3-(4-Chlorophenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(4-Chlorophenyl)propan-1-ol

3- (4-chlorophenyl) propanol (17.1g, 0.1mol) was added to DMF (150ml) added successively N- (3- chloropropyl) piperidine (17.8g, 0.11mol), potassium carbonate (6.9g, 0.05mol), potassium iodide 1g, was heated to 95 , the reaction was stirred for 12 hours.The mixture was cooled to room temperature, then diluted with 300ml water, extracted twice with 400ml of ethyl acetate, the combined organic phases, 2N sodium hydroxide and twice with brine, dried over magnesium sulfate, filtered, and HCl at room temperature gas, stirring the precipitated solid was filtered and dried to give light yellow solid solution of 29.8 g, yield 89.7%, HPLC: 99.6%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol.

Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
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Synthetic Route of 2867-59-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-aminobutan-1 -ol (500 mg, 5.61 mmol, 1 eq) in anhydrous DCM (25 ml_), cata- lytic amount of DMF (43 mI_, 0.56 mmol, 0.1 eq) was added, followed by dropwise addition of thionyl chloride (610 mI_, 8.414 mmol, 1.5 eq). The reaction was carried out 40C for 1 h, and continued at rt for further 16 h. The solvents were removed in vacuo. The residue was triturated using Et2Patent; RYVU THERAPEUTICS S.A.; DOBRZANSKA, Monika Patrycja; ZAWADZKA, Magdalena Izabela; RADZIMIERSKI, Adam; TOPOLNICKI, Grzegorz Witold; CWIERTNIA, Grzegorz Wojciech; MAHAJAN, Tushar Ravindra; FABRITIUS, Charles-Henry; CHMIELEWSKI, Stefan; GLUZA, Karolina Maria; ALVAREZ, Jose; ROGACKI, Maciej Krzysztof; MROCZKOWSKA, Magdalena; (215 pag.)WO2019/238786; (2019); A1;,
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Synthetic Route of 109240-30-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109240-30-4, name is 1-(4-Bromophenyl)cyclopropanol. A new synthetic method of this compound is introduced below.

General procedure: An argon-degassed solution of cyclopropanol 1 (2 equiv) in t-BuOH (0.0625 M) was added dropwise over 3 h to an argondegassed,stirred solution of acrylamide 4 (1 equiv) and manganese(III) acetylacetonate (2.2 equiv) in t-BuOH (0.114 M) at 26C. The resulting solution (0.03 M with respect to the cyclopropanol)was stirred for an additional 5 min before the solventwas removed under reduced pressure and the resulting residuepurified by flash chromatography to yield the desired oxindole.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109240-30-4, its application will become more common.

Reference:
Article; Davis, Dexter C.; Haskins, Christopher W.; Dai, Mingji; Synlett; vol. 28; 8; (2017); p. 913 – 918;,
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